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Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model.

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Title: Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model.
Authors: Morita M; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK., Arshad F; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK., Quayle LA; Department of Computing, Sheffield Hallam University, Cantor Building, Arundel Street, Sheffield, UK., George CN; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK., Lefley DV; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK., Kalajzic I; Reconstructive Sciences, UConn Health, Farmington, CT. USA., Balsubramanian M; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.; Highly specialised Osteogenesis Imparfecta Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK., Cebe T; INSIGNIO Institute for in silico Medicine and the Kroto Research Institute, Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK., Reilly G; INSIGNIO Institute for in silico Medicine and the Kroto Research Institute, Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK., Bishop NJ; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.; Highly specialised Osteogenesis Imparfecta Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK., Ottewell PD; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.
Source: Bone reports [Bone Rep] 2024 Jul 25; Vol. 22, pp. 101795. Date of Electronic Publication: 2024 Jul 25 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101646176 Publication Model: eCollection Cited Medium: Print ISSN: 2352-1872 (Print) Linking ISSN: 23521872 NLM ISO Abbreviation: Bone Rep Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model.
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  Data: <searchLink fieldCode="AU" term="%22Morita+M%22">Morita M</searchLink>; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Arshad+F%22">Arshad F</searchLink>; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Quayle+LA%22">Quayle LA</searchLink>; Department of Computing, Sheffield Hallam University, Cantor Building, Arundel Street, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22George+CN%22">George CN</searchLink>; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Lefley+DV%22">Lefley DV</searchLink>; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Kalajzic+I%22">Kalajzic I</searchLink>; Reconstructive Sciences, UConn Health, Farmington, CT. USA.<br /><searchLink fieldCode="AU" term="%22Balsubramanian+M%22">Balsubramanian M</searchLink>; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.; Highly specialised Osteogenesis Imparfecta Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Cebe+T%22">Cebe T</searchLink>; INSIGNIO Institute for in silico Medicine and the Kroto Research Institute, Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Reilly+G%22">Reilly G</searchLink>; INSIGNIO Institute for in silico Medicine and the Kroto Research Institute, Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Bishop+NJ%22">Bishop NJ</searchLink>; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.; Highly specialised Osteogenesis Imparfecta Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Ottewell+PD%22">Ottewell PD</searchLink>; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.
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  Data: <searchLink fieldCode="JN" term="%22101646176%22">Bone reports</searchLink> [Bone Rep] 2024 Jul 25; Vol. 22, pp. 101795. <i>Date of Electronic Publication: </i>2024 Jul 25 (<i>Print Publication: </i>2024).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101646176 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2352-1872 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223521872%22">23521872 </searchLink><i>NLM ISO Abbreviation: </i>Bone Rep <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39185375
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        Value: 10.1016/j.bonr.2024.101795
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        Text: English
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        StartPage: 101795
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              Text: 2024 Jul 25
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