Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.
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| Title: | Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4. |
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| Authors: | Ashton TD; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Calic PPS; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Dans MG; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Kang Ooi Z; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia., Zhou Q; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia., Loi K; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Jarman KE; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Palandri J; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Qiu D; Research School of Biology, Australian National University, Canberra, 2601, Australia., Lehane AM; Research School of Biology, Australian National University, Canberra, 2601, Australia., Maity B; TCG Lifesciences, Kolkata, West Bengal, 700091, India., De N; TCG Lifesciences, Kolkata, West Bengal, 700091, India., Famodimu MT; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK., Delves MJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK., Mao EY; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia., Gancheva MR; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia., Wilson DW; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia., Chowdury M; School of Medicine, Deakin University, Waurn Ponds, Victoria, 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, 3216, Australia., de Koning-Ward TF; School of Medicine, Deakin University, Waurn Ponds, Victoria, 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, 3216, Australia., Baud D; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215, Geneva, Switzerland., Brand S; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215, Geneva, Switzerland., Jackson PF; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC, La Jolla, California, 92121, USA., Cowman AF; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Sleebs BE; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia. |
| Source: | ChemMedChem [ChemMedChem] 2024 Dec 16; Vol. 19 (24), pp. e202400549. Date of Electronic Publication: 2024 Oct 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1860-7187 |
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| DOI: | 10.1002/cmdc.202400549 |
