RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy.

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Title: RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy.
Authors: Burrows DJ; Sheffield Institute for Translational Neuroscience, Division of Neuroscience, University of Sheffield, Sheffield, UK., McGown A; Sheffield Institute for Translational Neuroscience, Division of Neuroscience, University of Sheffield, Sheffield, UK., Abduljabbar O; Sheffield Institute for Translational Neuroscience, Division of Neuroscience, University of Sheffield, Sheffield, UK., Castelli LM; Sheffield Institute for Translational Neuroscience, Division of Neuroscience, University of Sheffield, Sheffield, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience, Division of Neuroscience, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK., Hautbergue GM; Sheffield Institute for Translational Neuroscience, Division of Neuroscience, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK.; Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK., Ramesh TM; Sheffield Institute for Translational Neuroscience, Division of Neuroscience, University of Sheffield, Sheffield, UK.; Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.
Source: Annals of neurology [Ann Neurol] 2024 Dec; Vol. 96 (6), pp. 1058-1069. Date of Electronic Publication: 2024 Aug 31.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1531-8249
DOI:10.1002/ana.27068