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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.

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Title: Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Authors: Vandyck K; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., McGowan DC; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Luong XG; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Stevens SK; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Jekle A; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Gupta K; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Misner DL; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Chanda S; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Serebryany V; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Welch M; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Hu H; Pharmaron, 6 Taihe Road, BDA, Beijing, 100176, P. R. China., Lv Z; Pharmaron, 6 Taihe Road, BDA, Beijing, 100176, P. R. China., Williams C; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Maskos K; Proteros Biostructures GmbH, Bunsenstraße 7a, 82152 Planegg-Martinsried, Germany., Lammens A; Proteros Biostructures GmbH, Bunsenstraße 7a, 82152 Planegg-Martinsried, Germany., Stoycheva AD; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Lin TI; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Blatt LM; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Beigelman LN; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Symons JA; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Raboisson P; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Deval J; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 14840-14851. Date of Electronic Publication: 2024 Sep 02.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.4c01029