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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.

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Title: Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Authors: Vandyck K; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., McGowan DC; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Luong XG; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Stevens SK; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Jekle A; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Gupta K; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Misner DL; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Chanda S; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Serebryany V; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Welch M; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Hu H; Pharmaron, 6 Taihe Road, BDA, Beijing, 100176, P. R. China., Lv Z; Pharmaron, 6 Taihe Road, BDA, Beijing, 100176, P. R. China., Williams C; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Maskos K; Proteros Biostructures GmbH, Bunsenstraße 7a, 82152 Planegg-Martinsried, Germany., Lammens A; Proteros Biostructures GmbH, Bunsenstraße 7a, 82152 Planegg-Martinsried, Germany., Stoycheva AD; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Lin TI; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Blatt LM; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Beigelman LN; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Symons JA; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Raboisson P; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States., Deval J; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 14840-14851. Date of Electronic Publication: 2024 Sep 02.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
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  Data: <searchLink fieldCode="AU" term="%22Vandyck+K%22">Vandyck K</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22McGowan+DC%22">McGowan DC</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Luong+XG%22">Luong XG</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Stevens+SK%22">Stevens SK</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Jekle+A%22">Jekle A</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Gupta+K%22">Gupta K</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Misner+DL%22">Misner DL</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Chanda+S%22">Chanda S</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Serebryany+V%22">Serebryany V</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Welch+M%22">Welch M</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Pharmaron, 6 Taihe Road, BDA, Beijing, 100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lv+Z%22">Lv Z</searchLink>; Pharmaron, 6 Taihe Road, BDA, Beijing, 100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Williams+C%22">Williams C</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Maskos+K%22">Maskos K</searchLink>; Proteros Biostructures GmbH, Bunsenstraße 7a, 82152 Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Lammens+A%22">Lammens A</searchLink>; Proteros Biostructures GmbH, Bunsenstraße 7a, 82152 Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Stoycheva+AD%22">Stoycheva AD</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Lin+TI%22">Lin TI</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Blatt+LM%22">Blatt LM</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Beigelman+LN%22">Beigelman LN</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Symons+JA%22">Symons JA</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Raboisson+P%22">Raboisson P</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Deval+J%22">Deval J</searchLink>; Aligos Therapeutics, Incorporated, 1 Corporate Drive, South San Francisco, California 94080, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 14840-14851. <i>Date of Electronic Publication: </i>2024 Sep 02.
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