Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis.

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Title: Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis.
Authors: Lee K; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, 14623, USA., Dissanayake W; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, 14623, USA.; Department of Biology, University of Rochester, Rochester, NY, USA., MacLiesh M; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, 14623, USA.; Department of Biology, University of Rochester, Rochester, NY, USA., Hong CL; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, 14623, USA.; Department of Physiology/Pharmacology, University of Rochester Medical Center, Rochester, NY, USA., Yin Z; Institute of Optics, University of Rochester, Rochester, NY, USA., Kawano Y; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA., Kaszuba CM; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Kawano H; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA., Quarato ER; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Toxicology, University of Rochester Medical Center, Rochester, NY, USA., Marples B; Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA., Becker M; Department of Medicine, Indiana University, Indianapolis, IN, USA., Bajaj J; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA., Calvi LM; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, 14623, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA., Yeh SA; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA. ShuChi_Yeh@URMC.Rochester.edu.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, 14623, USA. ShuChi_Yeh@URMC.Rochester.edu.; Department of Physiology/Pharmacology, University of Rochester Medical Center, Rochester, NY, USA. ShuChi_Yeh@URMC.Rochester.edu.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. ShuChi_Yeh@URMC.Rochester.edu.
Source: Scientific reports [Sci Rep] 2024 Sep 03; Vol. 14 (1), pp. 20486. Date of Electronic Publication: 2024 Sep 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2045-2322
DOI:10.1038/s41598-024-71307-4