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Patient-derived Organoid Pharmacotyping as a Predictive Tool for Therapeutic Selection in Pancreatic Ductal Adenocarcinoma.

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Title: Patient-derived Organoid Pharmacotyping as a Predictive Tool for Therapeutic Selection in Pancreatic Ductal Adenocarcinoma.
Authors: Nicolson NG; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD., Tandurella JA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA., Wu LW; Department of Medicine, Johns Hopkins Hospital, Baltimore, MD.; Division of Hematology and Medical Oncology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Patel J; Department of Cancer Biology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and Tays Cancer Centre, Tampere, Finland., Morris E; Department of Medicine, Johns Hopkins Hospital, Baltimore, MD., Seppälä TT; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.; Department of Cancer Biology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and Tays Cancer Centre, Tampere, Finland., Guinn S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD., Zlomke H; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.; Department of Surgery, Medical University of South Carolina, Charleston, SC., Shubert CR; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD., Lafaro KJ; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD., Burns WR; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD., Cameron JL; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD., He J; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD., Fertig EJ; Division of Quantitative Sciences, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.; Department of Oncology, Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD., Jaffee EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.; Department of Oncology, Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD., Zimmerman JW; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.; Department of Oncology, Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD., Burkhart RA; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.; Department of Oncology, Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Source: Annals of surgery [Ann Surg] 2026 Jun 01; Vol. 283 (6), pp. e8-e18. Date of Electronic Publication: 2024 Sep 04.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0372354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1140 (Electronic) Linking ISSN: 00034932 NLM ISO Abbreviation: Ann Surg Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Patient-derived Organoid Pharmacotyping as a Predictive Tool for Therapeutic Selection in Pancreatic Ductal Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Nicolson+NG%22">Nicolson NG</searchLink>; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Tandurella+JA%22">Tandurella JA</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Wu+LW%22">Wu LW</searchLink>; Department of Medicine, Johns Hopkins Hospital, Baltimore, MD.; Division of Hematology and Medical Oncology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.<br /><searchLink fieldCode="AU" term="%22Patel+J%22">Patel J</searchLink>; Department of Cancer Biology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and Tays Cancer Centre, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Morris+E%22">Morris E</searchLink>; Department of Medicine, Johns Hopkins Hospital, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Seppälä+TT%22">Seppälä TT</searchLink>; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.; Department of Cancer Biology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and Tays Cancer Centre, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Guinn+S%22">Guinn S</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Zlomke+H%22">Zlomke H</searchLink>; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.; Department of Surgery, Medical University of South Carolina, Charleston, SC.<br /><searchLink fieldCode="AU" term="%22Shubert+CR%22">Shubert CR</searchLink>; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Lafaro+KJ%22">Lafaro KJ</searchLink>; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Burns+WR%22">Burns WR</searchLink>; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Cameron+JL%22">Cameron JL</searchLink>; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22He+J%22">He J</searchLink>; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Fertig+EJ%22">Fertig EJ</searchLink>; Division of Quantitative Sciences, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.; Department of Oncology, Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Jaffee+EM%22">Jaffee EM</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.; Department of Oncology, Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Zimmerman+JW%22">Zimmerman JW</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.; Department of Oncology, Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Burkhart+RA%22">Burkhart RA</searchLink>; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.; Department of Oncology, Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
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  Data: <searchLink fieldCode="JN" term="%220372354%22">Annals of surgery</searchLink> [Ann Surg] 2026 Jun 01; Vol. 283 (6), pp. e8-e18. <i>Date of Electronic Publication: </i>2024 Sep 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-1140 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200034932%22">00034932 </searchLink><i>NLM ISO Abbreviation: </i>Ann Surg <i>Subsets: </i>MEDLINE
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