Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers.
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| Title: | Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers. |
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| Authors: | Sundaram L; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA.; Illumina AI laboratory, Illumina Inc, Foster City, CA, USA.; NVIDIA Bio Research, NVIDIA, Santa Clara, CA, USA., Kumar A; Illumina AI laboratory, Illumina Inc, Foster City, CA, USA., Zatzman M; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Salcedo A; Illumina AI laboratory, Illumina Inc, Foster City, CA, USA., Ravindra N; Illumina AI laboratory, Illumina Inc, Foster City, CA, USA., Shams S; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA., Louie BH; Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA., Bagdatli ST; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA., Myers MA; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sarmashghi S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Choi HY; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.; Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA., Choi WY; UTHSC Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA., Yost KE; Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA., Zhao Y; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA., Granja JM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Hinoue T; Center for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Hayes DN; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.; Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.; UTHSC Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA., Cherniack A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Felau I; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Choudhry H; Department of Biochemistry, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia., Zenklusen JC; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Farh KK; Illumina AI laboratory, Illumina Inc, Foster City, CA, USA., McPherson A; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Curtis C; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Laird PW; Center for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Demchok JA; Center for Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA., Yang L; Center for Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA., Tarnuzzer R; Center for Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA., Caesar-Johnson SJ; Center for Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA., Wang Z; Center for Biomedical Informatics and Information Technology, National Cancer Institute, NIH, 9609 Medical Center Drive, Rockville, MD 20850, USA., Doane AS; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA., Khurana E; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA., Castro MAA; Bioinformatics and Systems Biology Laboratory, Federal University of Paraná, Curitiba 81520-260, Brazil., Lazar AJ; Departments of Pathology & Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Broom BM; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Weinstein JN; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030., Akbani R; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Kumar SV; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Raphael BJ; Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08540., Wong CK; Biomolecular Engineering Department, School of Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Stuart JM; Biomolecular Engineering Department, School of Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Safavi R; Biomolecular Engineering Department, School of Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Benz CC; Buck Institute for Research on Aging, Novato, CA 94945, USA., Johnson BK; Center for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Kyi C; Center for Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA., Shen H; Center for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Corces MR; Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA.; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Chang HY; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.; Howard Hughes Medical Institute, Stanford University, School of Medicine, Stanford, CA, USA., Greenleaf WJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.; Department of Applied Physics, Stanford University, Stanford, CA, USA. |
| Corporate Authors: | Cancer Genome Atlas Analysis Network‡ |
| Source: | Science (New York, N.Y.) [Science] 2024 Sep 06; Vol. 385 (6713), pp. eadk9217. Date of Electronic Publication: 2024 Sep 06. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adk9217 |
