Merging Natural Product Structures with Pharmaceutical Leads: Unnatural Enantiomers of Estranes as Glucocorticoid Receptor Modulators That Suppress TNF-α and IL-6 Release.
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| Title: | Merging Natural Product Structures with Pharmaceutical Leads: Unnatural Enantiomers of Estranes as Glucocorticoid Receptor Modulators That Suppress TNF-α and IL-6 Release. |
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| Authors: | Nicholson JM; 6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, United States., Yang D; Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, United States., Koelblen T; University of Florida Genetics Institute, Gainesville, Florida 32610, United States., Hu EL; Computational Biology Undergraduate Concentration, Brown University, 69 Brown Street, Mail no. 4277, Providence, Rhode Island 02912, United States., Coss CC; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States., Burris TP; University of Florida Genetics Institute, Gainesville, Florida 32610, United States., Hu X; Accunet LLC BioPharma Consulting, 1805 Olive Green Street, Chula Vista, California 91913, United States., Micalizio GC; 6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2024 Sep 26; Vol. 67 (18), pp. 16185-16194. Date of Electronic Publication: 2024 Sep 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39240657 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Merging Natural Product Structures with Pharmaceutical Leads: Unnatural Enantiomers of Estranes as Glucocorticoid Receptor Modulators That Suppress TNF-α and IL-6 Release. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nicholson+JM%22">Nicholson JM</searchLink>; 6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, United States.<br /><searchLink fieldCode="AU" term="%22Yang+D%22">Yang D</searchLink>; Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, United States.<br /><searchLink fieldCode="AU" term="%22Koelblen+T%22">Koelblen T</searchLink>; University of Florida Genetics Institute, Gainesville, Florida 32610, United States.<br /><searchLink fieldCode="AU" term="%22Hu+EL%22">Hu EL</searchLink>; Computational Biology Undergraduate Concentration, Brown University, 69 Brown Street, Mail no. 4277, Providence, Rhode Island 02912, United States.<br /><searchLink fieldCode="AU" term="%22Coss+CC%22">Coss CC</searchLink>; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.<br /><searchLink fieldCode="AU" term="%22Burris+TP%22">Burris TP</searchLink>; University of Florida Genetics Institute, Gainesville, Florida 32610, United States.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Accunet LLC BioPharma Consulting, 1805 Olive Green Street, Chula Vista, California 91913, United States.<br /><searchLink fieldCode="AU" term="%22Micalizio+GC%22">Micalizio GC</searchLink>; 6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Sep 26; Vol. 67 (18), pp. 16185-16194. <i>Date of Electronic Publication: </i>2024 Sep 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39240657 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.4c01007 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 16185 Titles: – TitleFull: Merging Natural Product Structures with Pharmaceutical Leads: Unnatural Enantiomers of Estranes as Glucocorticoid Receptor Modulators That Suppress TNF-α and IL-6 Release. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nicholson JM – PersonEntity: Name: NameFull: Yang D – PersonEntity: Name: NameFull: Koelblen T – PersonEntity: Name: NameFull: Hu EL – PersonEntity: Name: NameFull: Coss CC – PersonEntity: Name: NameFull: Burris TP – PersonEntity: Name: NameFull: Hu X – PersonEntity: Name: NameFull: Micalizio GC IsPartOfRelationships: – BibEntity: Dates: – D: 26 M: 09 Text: 2024 Sep 26 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 67 – Type: issue Value: 18 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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