Mirtazapine to alleviate severe breathlessness in patients with COPD or interstitial lung diseases (BETTER-B): an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial.

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Title: Mirtazapine to alleviate severe breathlessness in patients with COPD or interstitial lung diseases (BETTER-B): an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial.
Authors: Higginson IJ; Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK; King's College Hospital NHS Foundation Trust, London, UK. Electronic address: irene.higginson@kcl.ac.uk., Brown ST; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK., Oluyase AO; Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK., May P; Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK; School of Medicine, Trinity College Dublin, Dublin, Ireland., Maddocks M; Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK., Costantini M; Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK., Bajwah S; Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK; King's College Hospital NHS Foundation Trust, London, UK., Normand C; Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK; School of Medicine, Trinity College Dublin, Dublin, Ireland., Bausewein C; LMU University Hospital, Department for Palliative Medicine, Ludwig-Maximilians-University Muenchen, Munich, Germany., Simon ST; University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine and Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany., Ryan K; University College Dublin and Mater Misericordiae University Hospital Dublin, Dublin, Ireland., Currow DC; Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia., Johnson MJ; Wolfson Palliative Care Research Centre, Hull York Medical School, The University of Hull, Hull, UK., Hart SP; Respiratory Research Group, Hull York Medical School, The University of Hull, Hull, UK., Mather H; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK., Krajnik M; Department of Palliative Care, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland., Tanzi S; Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Ghirotto L; Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Bolton CE; NIHR Nottingham Biomedical Research Centre, Translational Medical Sciences, School of Medicine, The University of Nottingham, Nottingham, UK., Janowiak P; Division of Pulmonology, Gdanski Uniwersytet Medyczny, Gdańsk, Poland., Turola E; Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Jolley CJ; King's College Hospital NHS Foundation Trust, London, UK; Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, King's College London, London, UK., Murden G; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK., Wilcock A; Department of Clinical Oncology, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK., Farsides B; Brighton and Sussex Medical School, University of Sussex, Brighton, UK., Brown JM; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Corporate Authors: BETTER-B consortium
Source: The Lancet. Respiratory medicine [Lancet Respir Med] 2024 Oct; Vol. 12 (10), pp. 763-774. Date of Electronic Publication: 2024 Sep 09.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase III; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-2619
DOI:10.1016/S2213-2600(24)00187-5