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A humanized ACE2 mouse model recapitulating age- and sex-dependent immunopathogenesis of COVID-19.

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Title: A humanized ACE2 mouse model recapitulating age- and sex-dependent immunopathogenesis of COVID-19.
Authors: Park U; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, South Korea., Lee JH; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.; GEMCRO Inc., Seoul, South Korea., Kim U; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea., Jeon K; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Kim Y; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, South Korea., Kim H; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Kang JI; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, South Korea., Park MY; GEMCRO Inc., Seoul, South Korea., Park SH; GEMCRO Inc., Seoul, South Korea., Cha JS; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea., Yoon GY; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea., Jeong DE; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Jeollabuk-do, South Korea., Kim T; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Oh S; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Yoon SH; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Department of Physiology & Biomedical Sciences, Ischemic/hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea., Jin L; Department of Physiology & Biomedical Sciences, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea., Ahn Y; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea., Lim MY; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea., Han SR; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, South Korea., Kim HY; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea., Kim MH; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Department of Physiology & Biomedical Sciences, Ischemic/hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea.; Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea., Zhang YH; Department of Physiology & Biomedical Sciences, Ischemic/hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea.; Department of Physiology & Biomedical Sciences, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea., Kang JG; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Jeollabuk-do, South Korea., Lee MS; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, South Korea., Jeon YK; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea., Cho HS; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea., Lee HW; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.; GEMCRO Inc., Seoul, South Korea., Cho NH; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, South Korea.; Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea.; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea.
Source: Journal of medical virology [J Med Virol] 2024 Sep; Vol. 96 (9), pp. e29915.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A humanized ACE2 mouse model recapitulating age- and sex-dependent immunopathogenesis of COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Park+U%22">Park U</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.; GEMCRO Inc., Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+U%22">Kim U</searchLink>; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+K%22">Jeon K</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+Y%22">Kim Y</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kang+JI%22">Kang JI</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+MY%22">Park MY</searchLink>; GEMCRO Inc., Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+SH%22">Park SH</searchLink>; GEMCRO Inc., Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Cha+JS%22">Cha JS</searchLink>; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+GY%22">Yoon GY</searchLink>; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+DE%22">Jeong DE</searchLink>; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Jeollabuk-do, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+T%22">Kim T</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Oh+S%22">Oh S</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+SH%22">Yoon SH</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Department of Physiology & Biomedical Sciences, Ischemic/hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Jin+L%22">Jin L</searchLink>; Department of Physiology & Biomedical Sciences, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Ahn+Y%22">Ahn Y</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lim+MY%22">Lim MY</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Han+SR%22">Han SR</searchLink>; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+HY%22">Kim HY</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+MH%22">Kim MH</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Department of Physiology & Biomedical Sciences, Ischemic/hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea.; Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea.<br /><searchLink fieldCode="AU" term="%22Zhang+YH%22">Zhang YH</searchLink>; Department of Physiology & Biomedical Sciences, Ischemic/hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea.; Department of Physiology & Biomedical Sciences, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kang+JG%22">Kang JG</searchLink>; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Jeollabuk-do, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+MS%22">Lee MS</searchLink>; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, South Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+YK%22">Jeon YK</searchLink>; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Cho+HS%22">Cho HS</searchLink>; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HW%22">Lee HW</searchLink>; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.; GEMCRO Inc., Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Cho+NH%22">Cho NH</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, South Korea.; Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea.; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea.
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