An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.

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Bibliographic Details
Title: An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.
Authors: Zhang Y; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Liu Z; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Hirschi M; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Brodsky O; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Johnson E; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Won SJ; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Nagata A; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Bezwada D; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Petroski MD; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA., Majmudar JD; Discovery Sciences, Pfizer Research and Development, Pfizer, Inc., Cambridge, MA, USA., Niessen S; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA.; Belharra Therapeutics, San Diego, CA, USA., VanArsdale T; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA., Gilbert AM; Discovery Sciences, Pfizer Research and Development, Pfizer, Inc., Groton, CT, USA., Hayward MM; Discovery Sciences, Pfizer Research and Development, Pfizer, Inc., Groton, CT, USA.; Magnet Biomedicine, Boston, MA, USA., Stewart AE; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Nager AR; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA., Melillo B; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. cravatt@scripps.edu.
Source: Nature chemical biology [Nat Chem Biol] 2025 Mar; Vol. 21 (3), pp. 420-431. Date of Electronic Publication: 2024 Sep 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1552-4469
DOI:10.1038/s41589-024-01738-7