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An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.

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Title: An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.
Authors: Zhang Y; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Liu Z; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Hirschi M; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Brodsky O; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Johnson E; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Won SJ; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Nagata A; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Bezwada D; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Petroski MD; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA., Majmudar JD; Discovery Sciences, Pfizer Research and Development, Pfizer, Inc., Cambridge, MA, USA., Niessen S; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA.; Belharra Therapeutics, San Diego, CA, USA., VanArsdale T; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA., Gilbert AM; Discovery Sciences, Pfizer Research and Development, Pfizer, Inc., Groton, CT, USA., Hayward MM; Discovery Sciences, Pfizer Research and Development, Pfizer, Inc., Groton, CT, USA.; Magnet Biomedicine, Boston, MA, USA., Stewart AE; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA., Nager AR; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA., Melillo B; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. cravatt@scripps.edu.
Source: Nature chemical biology [Nat Chem Biol] 2025 Mar; Vol. 21 (3), pp. 420-431. Date of Electronic Publication: 2024 Sep 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hirschi+M%22">Hirschi M</searchLink>; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Brodsky+O%22">Brodsky O</searchLink>; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+E%22">Johnson E</searchLink>; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Won+SJ%22">Won SJ</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nagata+A%22">Nagata A</searchLink>; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bezwada+D%22">Bezwada D</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Petroski+MD%22">Petroski MD</searchLink>; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Majmudar+JD%22">Majmudar JD</searchLink>; Discovery Sciences, Pfizer Research and Development, Pfizer, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Niessen+S%22">Niessen S</searchLink>; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA.; Belharra Therapeutics, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22VanArsdale+T%22">VanArsdale T</searchLink>; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+AM%22">Gilbert AM</searchLink>; Discovery Sciences, Pfizer Research and Development, Pfizer, Inc., Groton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hayward+MM%22">Hayward MM</searchLink>; Discovery Sciences, Pfizer Research and Development, Pfizer, Inc., Groton, CT, USA.; Magnet Biomedicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stewart+AE%22">Stewart AE</searchLink>; Medicine Design, Pfizer Research and Development, Pfizer, Inc., La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nager+AR%22">Nager AR</searchLink>; Oncology Research and Development, Pfizer, Inc., La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Melillo+B%22">Melillo B</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cravatt+BF%22">Cravatt BF</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. cravatt@scripps.edu.
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  Data: <searchLink fieldCode="JN" term="%22101231976%22">Nature chemical biology</searchLink> [Nat Chem Biol] 2025 Mar; Vol. 21 (3), pp. 420-431. <i>Date of Electronic Publication: </i>2024 Sep 18.
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