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Design, preparation and biological evaluation of new Rociletinib-inspired analogs as irreversible EGFR inhibitors to treat non-small-cell-lung cancer.

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Title: Design, preparation and biological evaluation of new Rociletinib-inspired analogs as irreversible EGFR inhibitors to treat non-small-cell-lung cancer.
Authors: Konsue A; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand., Lamtha T; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand., Gleeson D; Department of Chemistry & Applied Computational Chemistry Research Unit, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand., Jones DJL; Leicester Cancer Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom., Britton RG; Leicester Cancer Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom., Pickering JD; School of Chemistry, University of Leicester, Leicester LE1 7RH, United Kingdom., Choowongkomon K; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand., Gleeson MP; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand. Electronic address: paul.gl@kmitl.ac.th.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Nov 01; Vol. 113, pp. 117906. Date of Electronic Publication: 2024 Sep 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3391
DOI:10.1016/j.bmc.2024.117906