Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth.

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Title: Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth.
Authors: Zhang Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chen K; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Tang SC; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Cai Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Nambu A; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., See YX; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Fu C; Mechanobiology Institute, National University of Singapore, Singapore, Singapore., Raju A; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lebeau B; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Ling Z; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Chan JJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Tay Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Mutwil M; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Lakshmanan M; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tucker-Kellogg G; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; Computational Biology Programme, Faculty of Science, National University of Singapore, Singapore, Singapore., Chng WJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Centre for Translational Medicine, Singapore, Singapore.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), National University Health System (NUHS), Singapore, Singapore., Tenen DG; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Harvard Stem Cells Institute, Harvard Medical School, Boston, MA, USA., Osato M; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Tergaonkar V; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Fullwood MJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. mfullwood@ntu.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. mfullwood@ntu.edu.sg.; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. mfullwood@ntu.edu.sg.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Jan; Vol. 32 (1), pp. 137-149. Date of Electronic Publication: 2024 Sep 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1545-9985
DOI:10.1038/s41594-024-01391-7