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Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth.

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Title: Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth.
Authors: Zhang Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chen K; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Tang SC; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Cai Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Nambu A; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., See YX; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Fu C; Mechanobiology Institute, National University of Singapore, Singapore, Singapore., Raju A; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lebeau B; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Ling Z; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Chan JJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Tay Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Mutwil M; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Lakshmanan M; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tucker-Kellogg G; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; Computational Biology Programme, Faculty of Science, National University of Singapore, Singapore, Singapore., Chng WJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Centre for Translational Medicine, Singapore, Singapore.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), National University Health System (NUHS), Singapore, Singapore., Tenen DG; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Harvard Stem Cells Institute, Harvard Medical School, Boston, MA, USA., Osato M; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Tergaonkar V; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Fullwood MJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. mfullwood@ntu.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. mfullwood@ntu.edu.sg.; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. mfullwood@ntu.edu.sg.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Jan; Vol. 32 (1), pp. 137-149. Date of Electronic Publication: 2024 Sep 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tang+SC%22">Tang SC</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Nambu+A%22">Nambu A</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22See+YX%22">See YX</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Fu+C%22">Fu C</searchLink>; Mechanobiology Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Raju+A%22">Raju A</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lebeau+B%22">Lebeau B</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ling+Z%22">Ling Z</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+JJ%22">Chan JJ</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+Y%22">Tay Y</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Mutwil+M%22">Mutwil M</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lakshmanan+M%22">Lakshmanan M</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tucker-Kellogg+G%22">Tucker-Kellogg G</searchLink>; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; Computational Biology Programme, Faculty of Science, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chng+WJ%22">Chng WJ</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Centre for Translational Medicine, Singapore, Singapore.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), National University Health System (NUHS), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tenen+DG%22">Tenen DG</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Harvard Stem Cells Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Osato+M%22">Osato M</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tergaonkar+V%22">Tergaonkar V</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Fullwood+MJ%22">Fullwood MJ</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. mfullwood@ntu.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. mfullwood@ntu.edu.sg.; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. mfullwood@ntu.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%22101186374%22">Nature structural & molecular biology</searchLink> [Nat Struct Mol Biol] 2025 Jan; Vol. 32 (1), pp. 137-149. <i>Date of Electronic Publication: </i>2024 Sep 20.
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