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Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity.

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Title: Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity.
Authors: Herrmann A; Immunic AG, Gräfelfing, Germany. Electronic address: alexandra.herrmann@imux.com., Gege C; Immunic AG, Gräfelfing, Germany. Electronic address: christian.gege@imux.com., Wangen C; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: christina.wangen@uk-erlangen.de., Wagner S; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: sabrina.wagner@uk-erlangen.de., Kögler M; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: melanie.koegler@uk-erlangen.de., Cordsmeier A; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: arne.cordsmeier@uk-erlangen.de., Irrgang P; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: pascal.irrgang@uk-erlangen.de., Ip WH; Leibniz Institute of Virology, Hamburg, Germany. Electronic address: winghang.ip@leibniz-liv.de., Weil T; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: tatjanaweil@yahoo.de., Hunszinger V; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: victoria.hunszinger@uni-ulm.de., Groß R; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: ruediger.gross@uni-ulm.de., Heinen N; Ruhr-University Bochum, Department of Molecular and Medical Virology, Bochum, Germany. Electronic address: natalie.heinen@ruhr-uni-bochum.de., Pfaender S; Leibniz Institute of Virology, Hamburg, Germany; Ruhr-University Bochum, Department of Molecular and Medical Virology, Bochum, Germany; University of Luebeck, Department of Natural Sciences, Institute of Virology and Cell Biology, Lübeck, Germany. Electronic address: stephanie.pfaender@leibniz-liv.de., Reuter S; University Hospital Essen - Ruhrlandklinik, Department of Pulmonary Medicine, Experimental Pneumology, Essen, Germany. Electronic address: sebastian.reuter@rlk.uk-essen.de., Klopfleisch R; Institute for Animal Pathology, Freie Universität Berlin, Berlin, Germany. Electronic address: robert.klopfleisch@fu-berlin.de., Uhlig N; Fraunhofer Institute for Cell Therapy and Immunology, Preclinical Validation, Leipzig, Germany. Electronic address: nadja.uhlig@izi.fraunhofer.de., Eberlein V; Fraunhofer Institute for Cell Therapy and Immunology, Preclinical Validation, Leipzig, Germany. Electronic address: valentina.eberlein@izi.fraunhofer.de., Issmail L; Fraunhofer Institute for Cell Therapy and Immunology, Preclinical Validation, Leipzig, Germany. Electronic address: leila.issmail@izi.fraunhofer.de., Grunwald T; Fraunhofer Institute for Cell Therapy and Immunology, Preclinical Validation, Leipzig, Germany. Electronic address: thomas.grunwald@izi.fraunhofer.de., Hietel B; Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, Halle, Germany. Electronic address: benjamin.hietel@izi.fraunhofer.de., Cynis H; Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, Halle, Germany; Junior Research Group 'Immunomodulation in Pathophysiological Processes', Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle, Germany. Electronic address: holger.cynis@izi.fraunhofer.de., Münch J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: jan.muench@uni-ulm.de., Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: konstantin.sparrer@uni-ulm.de., Ensser A; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: armin.ensser@fau.de., Tenbusch M; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: matthias.tenbusch@fau.de., Dobner T; Leibniz Institute of Virology, Hamburg, Germany. Electronic address: thomas.dobner@leibniz-liv.de., Vitt D; Immunic AG, Gräfelfing, Germany. Electronic address: daniel.vitt@imux.com., Kohlhof H; Immunic AG, Gräfelfing, Germany. Electronic address: hella.kohlhof@imux.com., Hahn F; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: friedrich.hahn@uk-erlangen.de.
Source: Antiviral research [Antiviral Res] 2024 Nov; Vol. 231, pp. 106008. Date of Electronic Publication: 2024 Sep 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity.
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  Data: <searchLink fieldCode="AU" term="%22Herrmann+A%22">Herrmann A</searchLink>; Immunic AG, Gräfelfing, Germany. Electronic address: alexandra.herrmann@imux.com.<br /><searchLink fieldCode="AU" term="%22Gege+C%22">Gege C</searchLink>; Immunic AG, Gräfelfing, Germany. Electronic address: christian.gege@imux.com.<br /><searchLink fieldCode="AU" term="%22Wangen+C%22">Wangen C</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: christina.wangen@uk-erlangen.de.<br /><searchLink fieldCode="AU" term="%22Wagner+S%22">Wagner S</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: sabrina.wagner@uk-erlangen.de.<br /><searchLink fieldCode="AU" term="%22Kögler+M%22">Kögler M</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: melanie.koegler@uk-erlangen.de.<br /><searchLink fieldCode="AU" term="%22Cordsmeier+A%22">Cordsmeier A</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: arne.cordsmeier@uk-erlangen.de.<br /><searchLink fieldCode="AU" term="%22Irrgang+P%22">Irrgang P</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: pascal.irrgang@uk-erlangen.de.<br /><searchLink fieldCode="AU" term="%22Ip+WH%22">Ip WH</searchLink>; Leibniz Institute of Virology, Hamburg, Germany. Electronic address: winghang.ip@leibniz-liv.de.<br /><searchLink fieldCode="AU" term="%22Weil+T%22">Weil T</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: tatjanaweil@yahoo.de.<br /><searchLink fieldCode="AU" term="%22Hunszinger+V%22">Hunszinger V</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: victoria.hunszinger@uni-ulm.de.<br /><searchLink fieldCode="AU" term="%22Groß+R%22">Groß R</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: ruediger.gross@uni-ulm.de.<br /><searchLink fieldCode="AU" term="%22Heinen+N%22">Heinen N</searchLink>; Ruhr-University Bochum, Department of Molecular and Medical Virology, Bochum, Germany. Electronic address: natalie.heinen@ruhr-uni-bochum.de.<br /><searchLink fieldCode="AU" term="%22Pfaender+S%22">Pfaender S</searchLink>; Leibniz Institute of Virology, Hamburg, Germany; Ruhr-University Bochum, Department of Molecular and Medical Virology, Bochum, Germany; University of Luebeck, Department of Natural Sciences, Institute of Virology and Cell Biology, Lübeck, Germany. Electronic address: stephanie.pfaender@leibniz-liv.de.<br /><searchLink fieldCode="AU" term="%22Reuter+S%22">Reuter S</searchLink>; University Hospital Essen - Ruhrlandklinik, Department of Pulmonary Medicine, Experimental Pneumology, Essen, Germany. Electronic address: sebastian.reuter@rlk.uk-essen.de.<br /><searchLink fieldCode="AU" term="%22Klopfleisch+R%22">Klopfleisch R</searchLink>; Institute for Animal Pathology, Freie Universität Berlin, Berlin, Germany. Electronic address: robert.klopfleisch@fu-berlin.de.<br /><searchLink fieldCode="AU" term="%22Uhlig+N%22">Uhlig N</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology, Preclinical Validation, Leipzig, Germany. Electronic address: nadja.uhlig@izi.fraunhofer.de.<br /><searchLink fieldCode="AU" term="%22Eberlein+V%22">Eberlein V</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology, Preclinical Validation, Leipzig, Germany. Electronic address: valentina.eberlein@izi.fraunhofer.de.<br /><searchLink fieldCode="AU" term="%22Issmail+L%22">Issmail L</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology, Preclinical Validation, Leipzig, Germany. Electronic address: leila.issmail@izi.fraunhofer.de.<br /><searchLink fieldCode="AU" term="%22Grunwald+T%22">Grunwald T</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology, Preclinical Validation, Leipzig, Germany. Electronic address: thomas.grunwald@izi.fraunhofer.de.<br /><searchLink fieldCode="AU" term="%22Hietel+B%22">Hietel B</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, Halle, Germany. Electronic address: benjamin.hietel@izi.fraunhofer.de.<br /><searchLink fieldCode="AU" term="%22Cynis+H%22">Cynis H</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, Halle, Germany; Junior Research Group 'Immunomodulation in Pathophysiological Processes', Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle, Germany. Electronic address: holger.cynis@izi.fraunhofer.de.<br /><searchLink fieldCode="AU" term="%22Münch+J%22">Münch J</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: jan.muench@uni-ulm.de.<br /><searchLink fieldCode="AU" term="%22Sparrer+KMJ%22">Sparrer KMJ</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Electronic address: konstantin.sparrer@uni-ulm.de.<br /><searchLink fieldCode="AU" term="%22Ensser+A%22">Ensser A</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: armin.ensser@fau.de.<br /><searchLink fieldCode="AU" term="%22Tenbusch+M%22">Tenbusch M</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: matthias.tenbusch@fau.de.<br /><searchLink fieldCode="AU" term="%22Dobner+T%22">Dobner T</searchLink>; Leibniz Institute of Virology, Hamburg, Germany. Electronic address: thomas.dobner@leibniz-liv.de.<br /><searchLink fieldCode="AU" term="%22Vitt+D%22">Vitt D</searchLink>; Immunic AG, Gräfelfing, Germany. Electronic address: daniel.vitt@imux.com.<br /><searchLink fieldCode="AU" term="%22Kohlhof+H%22">Kohlhof H</searchLink>; Immunic AG, Gräfelfing, Germany. Electronic address: hella.kohlhof@imux.com.<br /><searchLink fieldCode="AU" term="%22Hahn+F%22">Hahn F</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: friedrich.hahn@uk-erlangen.de.
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  Data: <searchLink fieldCode="JN" term="%228109699%22">Antiviral research</searchLink> [Antiviral Res] 2024 Nov; Vol. 231, pp. 106008. <i>Date of Electronic Publication: </i>2024 Sep 19.
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