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Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts.

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Title: Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts.
Authors: Wani AH; Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA., Katrinli S; Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA., Zhao X; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Daskalakis NP; Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center of Excellence in Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA., Zannas AS; University of North Carolina at Chapel Hill, Carolina Stress Initiative, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Aiello AE; Robert N Butler Columbia Aging Center, Department of Epidemiology, Columbia University, New York, NY, USA., Baker DG; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.; Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA., Boks MP; Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht, UT, Netherlands., Brick LA; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA., Chen CY; Biogen Inc., Translational Sciences, Cambridge, MA, USA., Dalvie S; Department of Pathology, University of Cape Town, Cape Town, Western Province, South Africa.; Division of Human Genetics, University of Cape Town, Cape Town, Western Province, South Africa., Fortier C; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; VA Boston Healthcare System, TRACTS/GRECC, Boston, MA, USA., Geuze E; Brain Research and Innovation Centre, Netherlands Ministry of Defence, Utrecht, UT, Netherlands.; Department of Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, UT, Netherlands., Hayes JP; Department of Psychology, The Ohio State University, Columbus, OH, USA., Kessler RC; Department of Health Care Policy, Harvard Medical School, Boston, MA, USA., King AP; The Ohio State University, College of Medicine, Institute for Behavioral Medicine Research, Columbus, OH, USA., Koen N; Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, Western Province, South Africa.; University of Cape Town, Neuroscience Institute, Cape Town, Western Province, South Africa.; SA MRC Unit On Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, Western Province, South Africa., Liberzon I; Department of Psychiatry and Behavioral Sciences, Texas A&M University College of Medicine, Bryan, TX, USA., Lori A; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA., Luykx JJ; Department of Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, UT, Netherlands.; Department of Translational Neuroscience, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, UT, Netherlands., Maihofer AX; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.; Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA., Milberg W; VA Boston Healthcare System, GRECC/TRACTS, Boston, MA, USA., Miller MW; Boston University School of Medicine, Psychiatry, Boston, MA, USA.; VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA., Mufford MS; University of Cape Town, Neuroscience Institute, Cape Town, Western Province, South Africa.; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Province, South Africa., Nugent NR; Department of Emergency Medicine, Warren Alpert Brown Medical School, Providence, RI, USA.; Department of Pediatrics, Warren Alpert Brown Medical School, Providence, RI, USA.; Department of Psychiatry and Human Behavior, Warren Alpert Brown Medical School, Providence, RI, USA., Rauch S; Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, GA, USA.; Joseph Maxwell Cleland Atlanta Veterans Affairs Medical Center, Mental Health Service Line, Atlanta, USA., Ressler KJ; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.; McLean Hospital, Belmont, MA, USA., Risbrough VB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.; Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA., Rutten BPF; School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht Universitair Medisch Centrum, Maastricht, Limburg, Netherlands., Stein DJ; Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, Western Province, South Africa.; University of Cape Town, Neuroscience Institute, Cape Town, Western Province, South Africa.; SA MRC Unit On Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, Western Province, South Africa., Stein MB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.; School of Public Health, University of California San Diego, La Jolla, CA, USA., Ursano RJ; Department of Psychiatry, Uniformed Services University, Bethesda, MD, USA., Verfaellie MH; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.; VA Boston Healthcare System, Memory Disorders Research Center, Boston, MA, USA., Vermetten E; Department of Psychiatry, Leiden University Medical Center, Leiden, ZH, Netherlands.; Department of Psychiatry, New York University School of Medicine, New York, NY, USA., Vinkers CH; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Holland, Netherlands.; Department of Anatomy and Neurosciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, Holland, Netherlands.; Department of Psychiatry, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, Holland, Netherlands., Ware EB; Survey Research Center, University of Michigan, Institute for Social Research, Ann Arbor, MI, USA., Wildman DE; Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA., Wolf EJ; VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Nievergelt CM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.; Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA., Logue MW; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.; Boston University School of Medicine, Psychiatry, Biomedical Genetics, Boston, MA, USA., Smith AK; Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.; Department of Human Genetics, Emory University, Atlanta, GA, USA., Uddin M; Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA. monica43@usf.edu.
Source: BMC medical genomics [BMC Med Genomics] 2024 Sep 27; Vol. 17 (1), pp. 235. Date of Electronic Publication: 2024 Sep 27.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101319628 Publication Model: Electronic Cited Medium: Internet ISSN: 1755-8794 (Electronic) Linking ISSN: 17558794 NLM ISO Abbreviation: BMC Med Genomics Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1755-8794
DOI:10.1186/s12920-024-02002-6