The epigenetic state of the cell of origin defines mechanisms of leukemogenesis.

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Title: The epigenetic state of the cell of origin defines mechanisms of leukemogenesis.
Authors: Li Z; Stem Cell Program and Stem Cell Transplantation Programs, Boston Children's Hospital, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Department of Hematology/Oncology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China., Fierstein S; Stem Cell Program and Stem Cell Transplantation Programs, Boston Children's Hospital, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Tanaka-Yano M; Stem Cell Program and Stem Cell Transplantation Programs, Boston Children's Hospital, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Frenis K; Stem Cell Program and Stem Cell Transplantation Programs, Boston Children's Hospital, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Chen CC; Stem Cell Program and Stem Cell Transplantation Programs, Boston Children's Hospital, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Wang D; Stem Cell Program and Stem Cell Transplantation Programs, Boston Children's Hospital, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Falchetti M; Federal University of Santa Catarina, Florianopolis, Brazil., Côté P; Massachusetts Institute of Technology, Cambridge, MA, USA., Curran C; Stem Cell Program and Stem Cell Transplantation Programs, Boston Children's Hospital, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Lu K; Massachusetts Institute of Technology, Cambridge, MA, USA., Liu T; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Orkin S; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Li H; Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pediatrics, University of California, San Diego, CA, USA., Lummertz da Rocha E; Federal University of Santa Catarina, Florianopolis, Brazil., Hu S; Department of Hematology/Oncology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China. hushaoyan@suda.edu.cn., Zhu Q; Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA. qian.zhu@bcm.edu., Rowe RG; Stem Cell Program and Stem Cell Transplantation Programs, Boston Children's Hospital, Boston, MA, USA. Grant_rowe@dfci.harvard.edu.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA. Grant_rowe@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. Grant_rowe@dfci.harvard.edu.
Source: Leukemia [Leukemia] 2025 Jan; Vol. 39 (1), pp. 87-97. Date of Electronic Publication: 2024 Oct 01.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/s41375-024-02428-y