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Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice.

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Title: Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice.
Authors: Dixon ED; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria., Claudel T; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria., Nardo AD; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria., Riva A; Chair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Germany., Fuchs CD; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria., Mlitz V; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria., Busslinger G; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria; Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria., Stojakovic T; Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Austria., Senéca J; Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna, Vienna, Austria; Department of Microbiology and Ecosystem Science, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria., Hinteregger H; Division of Molecular Biology and Biochemistry, Medical University of Graz, Austria., Grabner GF; Division of Molecular Biology and Biochemistry, Medical University of Graz, Austria., Kratky D; Division of Molecular Biology and Biochemistry, Medical University of Graz, Austria., Verkade H; Department of Paediatrics, University Medical Centre Groningen, Groningen, Netherlands., Zimmermann R; Institute of Molecular Biosciences, University of Graz, Graz, Austria., Haemmerle G; Institute of Molecular Biosciences, University of Graz, Graz, Austria., Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria. Electronic address: michael.trauner@meduniwien.ac.at.
Source: Journal of hepatology [J Hepatol] 2025 Apr; Vol. 82 (4), pp. 658-675. Date of Electronic Publication: 2024 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
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  Data: Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice.
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  Data: <searchLink fieldCode="AU" term="%22Dixon+ED%22">Dixon ED</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Claudel+T%22">Claudel T</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Nardo+AD%22">Nardo AD</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Riva+A%22">Riva A</searchLink>; Chair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Germany.<br /><searchLink fieldCode="AU" term="%22Fuchs+CD%22">Fuchs CD</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Mlitz+V%22">Mlitz V</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Busslinger+G%22">Busslinger G</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria; Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Scharnagl+H%22">Scharnagl H</searchLink>; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Stojakovic+T%22">Stojakovic T</searchLink>; Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Senéca+J%22">Senéca J</searchLink>; Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna, Vienna, Austria; Department of Microbiology and Ecosystem Science, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hinteregger+H%22">Hinteregger H</searchLink>; Division of Molecular Biology and Biochemistry, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Grabner+GF%22">Grabner GF</searchLink>; Division of Molecular Biology and Biochemistry, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Kratky+D%22">Kratky D</searchLink>; Division of Molecular Biology and Biochemistry, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Verkade+H%22">Verkade H</searchLink>; Department of Paediatrics, University Medical Centre Groningen, Groningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Zimmermann+R%22">Zimmermann R</searchLink>; Institute of Molecular Biosciences, University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Haemmerle+G%22">Haemmerle G</searchLink>; Institute of Molecular Biosciences, University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Trauner+M%22">Trauner M</searchLink>; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria. Electronic address: michael.trauner@meduniwien.ac.at.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2025 Apr; Vol. 82 (4), pp. 658-675. <i>Date of Electronic Publication: </i>2024 Sep 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8503886 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1600-0641 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201688278%22">01688278 </searchLink><i>NLM ISO Abbreviation: </i>J Hepatol <i>Subsets: </i>MEDLINE
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