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The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding.

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Title: The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding.
Authors: Sims MC; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Haematology, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield, United Kingdom.; Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom., Gierula M; Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom., Stephens JC; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health and Care Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom., Tokolyi A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Stefanucci L; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom., Persyn E; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Sun L; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Collins JH; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Haematology, Barts Health National Health Service Trust, London, United Kingdom., Davenport EE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Di Angelantonio E; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; Health Data Science Centre, Human Technopole, Milan, Italy., Downes K; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Cambridge Genomics Laboratory, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom., Inouye M; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia., Paul DS; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Thomas W; Department of Haematology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom., Tolios A; Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, Vienna, Austria., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Haematology, University College London Hospitals National Health Service Trust, London, United Kingdom., Gleadall NS; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Crawley JTB; Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom., Butterworth AS; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Frontini M; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom., Ahnström J; Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom.
Source: Blood advances [Blood Adv] 2025 Jan 14; Vol. 9 (1), pp. 132-142.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE
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  Data: The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding.
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  Data: <searchLink fieldCode="AU" term="%22Sims+MC%22">Sims MC</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Haematology, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield, United Kingdom.; Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gierula+M%22">Gierula M</searchLink>; Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stephens+JC%22">Stephens JC</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health and Care Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tokolyi+A%22">Tokolyi A</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stefanucci+L%22">Stefanucci L</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Persyn+E%22">Persyn E</searchLink>; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sun+L%22">Sun L</searchLink>; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Collins+JH%22">Collins JH</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Haematology, Barts Health National Health Service Trust, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Davenport+EE%22">Davenport EE</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Di+Angelantonio+E%22">Di Angelantonio E</searchLink>; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; Health Data Science Centre, Human Technopole, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Downes+K%22">Downes K</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Cambridge Genomics Laboratory, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Inouye+M%22">Inouye M</searchLink>; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Paul+DS%22">Paul DS</searchLink>; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Thomas+W%22">Thomas W</searchLink>; Department of Haematology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tolios+A%22">Tolios A</searchLink>; Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Ouwehand+WH%22">Ouwehand WH</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Haematology, University College London Hospitals National Health Service Trust, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gleadall+NS%22">Gleadall NS</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Crawley+JTB%22">Crawley JTB</searchLink>; Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Butterworth+AS%22">Butterworth AS</searchLink>; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Frontini+M%22">Frontini M</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ahnström+J%22">Ahnström J</searchLink>; Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom.
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