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Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy.

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Title: Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy.
Authors: Kang TG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Lan X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN 38105, USA., Mi T; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Chen H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Alli S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Lim SE; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN 38105, USA.; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Bhatara S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Vasandan AB; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Ward G; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Bentivegna S; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.; Biotech Research and Innovation Center (BRIC), University of Copenhagen, DK-2200 Copenhagen, Denmark., Jang J; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Spatz ML; Merck & Co. Inc., Rahway, NJ 07065, USA., Han JH; Merck & Co. Inc., Rahway, NJ 07065, USA., Schlotmann BC; The Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark., Jespersen JS; Biotech Research and Innovation Center (BRIC), University of Copenhagen, DK-2200 Copenhagen, Denmark., Derenzo C; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Vogel P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Baylin S; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Institute at Johns Hopkins, Baltimore, MD 21231, USA., Jones P; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., O'Connell C; Jane Anne Nohl Division of Hematology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Grønbæk K; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.; Biotech Research and Innovation Center (BRIC), University of Copenhagen, DK-2200 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark., Youngblood B; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Zebley CC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Source: Science (New York, N.Y.) [Science] 2024 Oct 11; Vol. 386 (6718), pp. eadl4492. Date of Electronic Publication: 2024 Oct 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1095-9203
DOI:10.1126/science.adl4492