A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival.

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Title: A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival.
Authors: Abassah-Oppong S; Department of Biological Sciences, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada.; Department of Biological Sciences, Fort Hays State University, Hays, KS, 67601, USA., Zoia M; Department for BioMedical Research (DBMR), University of Bern, 3008, Bern, Switzerland., Mannion BJ; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; Comparative Biochemistry Program, University of California, Berkeley, CA, 94720, USA., Rouco R; Department of Genetic Medicine and Development and iGE3, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Tissières V; Department for BioMedical Research (DBMR), University of Bern, 3008, Bern, Switzerland.; Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, 41013, Seville, Spain.; Department of Cardiology, Bern University Hospital, 3010, Bern, Switzerland., Spurrell CH; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Roland V; Department for BioMedical Research (DBMR), University of Bern, 3008, Bern, Switzerland., Darbellay F; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; Department of Genetic Medicine and Development and iGE3, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Itum A; Department of Biological Sciences, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada., Gamart J; Department for BioMedical Research (DBMR), University of Bern, 3008, Bern, Switzerland.; Department of Cardiology, Bern University Hospital, 3010, Bern, Switzerland., Festa-Daroux TA; Department of Biological Sciences, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada., Sullivan CS; Department of Biological Sciences, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada., Kosicki M; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Rodríguez-Carballo E; Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.; Department of Molecular Biology, University of Geneva, Geneva, Switzerland., Fukuda-Yuzawa Y; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Hunter RD; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Novak CS; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Plajzer-Frick I; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Tran S; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Akiyama JA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Dickel DE; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Lopez-Rios J; Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, 41013, Seville, Spain.; School of Health Sciences, Universidad Loyola Andalucía, Seville, Spain., Barozzi I; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; Center for Cancer Research, Medical University of Vienna, Vienna, Austria., Andrey G; Department of Genetic Medicine and Development and iGE3, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Visel A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; School of Natural Sciences, University of California, Merced, Merced, CA, 95343, USA., Pennacchio LA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; Comparative Biochemistry Program, University of California, Berkeley, CA, 94720, USA.; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Cobb J; Department of Biological Sciences, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada. jacobb@ucalgary.ca., Osterwalder M; Department for BioMedical Research (DBMR), University of Bern, 3008, Bern, Switzerland. marco.osterwalder@unibe.ch.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA. marco.osterwalder@unibe.ch.; Department of Cardiology, Bern University Hospital, 3010, Bern, Switzerland. marco.osterwalder@unibe.ch.
Source: Nature communications [Nat Commun] 2024 Oct 10; Vol. 15 (1), pp. 8793. Date of Electronic Publication: 2024 Oct 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-024-53009-7