Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen.

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Title: Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen.
Authors: He K; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Xiao H; Center for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Joint CMU-Pitt PhD Program in Computational Biology, Pittsburgh, PA, USA., MacDonald WA; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Health Sciences Sequencing Core, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Mehta I; Center for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Kishore A; Center for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Vincent A; Center for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Xu Z; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Beijing, China., Ray A; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Chen W; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Weaver CT; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Lambrecht BN; Laboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Department of Pulmonary Medicine, Erasmus MC, Rotterdam, the Netherlands., Das J; Center for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Poholek AC; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. poholeka@pitt.edu.; Center for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. poholeka@pitt.edu.
Source: Nature immunology [Nat Immunol] 2024 Nov; Vol. 25 (11), pp. 2124-2139. Date of Electronic Publication: 2024 Oct 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-024-01986-8