Site-specific m6A-miR-494-3p, not unmethylated miR-494-3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis.
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| Title: | Site-specific m6A-miR-494-3p, not unmethylated miR-494-3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis. |
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| Authors: | Woudenberg T; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., van der Bent ML; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Kremer V; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC Location VUMc, Vrije Universiteit, Amsterdam, The Netherlands., Waas ISE; Department of Pathology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands., Daemen MJAP; Department of Pathology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands., Boon RA; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC Location VUMc, Vrije Universiteit, Amsterdam, The Netherlands.; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine Goethe University, Frankfurt am Main, Germany.; German Center for Cardiovascular Research (DZHK), Frankfurt am Main, Germany., Quax PHA; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Nossent AY; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. |
| Source: | British journal of pharmacology [Br J Pharmacol] 2025 Sep; Vol. 182 (18), pp. 4221-4235. Date of Electronic Publication: 2024 Oct 17. |
| Publication Type: | Journal Article; Review |
| Journal Info: | Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1476-5381 |
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| DOI: | 10.1111/bph.17374 |
