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Site-specific m6A-miR-494-3p, not unmethylated miR-494-3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis.

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Title: Site-specific m6A-miR-494-3p, not unmethylated miR-494-3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis.
Authors: Woudenberg T; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., van der Bent ML; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Kremer V; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC Location VUMc, Vrije Universiteit, Amsterdam, The Netherlands., Waas ISE; Department of Pathology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands., Daemen MJAP; Department of Pathology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands., Boon RA; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC Location VUMc, Vrije Universiteit, Amsterdam, The Netherlands.; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine Goethe University, Frankfurt am Main, Germany.; German Center for Cardiovascular Research (DZHK), Frankfurt am Main, Germany., Quax PHA; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Nossent AY; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Source: British journal of pharmacology [Br J Pharmacol] 2025 Sep; Vol. 182 (18), pp. 4221-4235. Date of Electronic Publication: 2024 Oct 17.
Publication Type: Journal Article; Review
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Site-specific m6A-miR-494-3p, not unmethylated miR-494-3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Woudenberg+T%22">Woudenberg T</searchLink>; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Bent+ML%22">van der Bent ML</searchLink>; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kremer+V%22">Kremer V</searchLink>; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC Location VUMc, Vrije Universiteit, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Waas+ISE%22">Waas ISE</searchLink>; Department of Pathology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Daemen+MJAP%22">Daemen MJAP</searchLink>; Department of Pathology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Boon+RA%22">Boon RA</searchLink>; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC Location VUMc, Vrije Universiteit, Amsterdam, The Netherlands.; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine Goethe University, Frankfurt am Main, Germany.; German Center for Cardiovascular Research (DZHK), Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Quax+PHA%22">Quax PHA</searchLink>; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nossent+AY%22">Nossent AY</searchLink>; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2025 Sep; Vol. 182 (18), pp. 4221-4235. <i>Date of Electronic Publication: </i>2024 Oct 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7502536 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5381 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200071188%22">00071188 </searchLink><i>NLM ISO Abbreviation: </i>Br J Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1111/bph.17374
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              Text: 2025 Sep
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