Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial.

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Title: Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial.
Authors: Leikas AJ; Heart Center, Kuopio University Hospital, Kuopio, Finland aleksi.leikas@uef.fi.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland., Hartikainen JEK; Heart Center, Kuopio University Hospital, Kuopio, Finland.; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Kastrup J; Cardiology Stem Cell Centre, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark., Mathur A; Centre for Cardiovascular Medicine and Devices, Queen Mary University of London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK.; NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Gyöngyösi M; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Fernández-Avilés F; Department of Cardiology, General University Gregorio Marañón Hospital, Madrid, Spain., Sanz-Ruiz R; Department of Cardiology, General University Gregorio Marañón Hospital, Madrid, Spain., Wojakowski W; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland., Gwizdała A; First Department of Cardiology, Poznań University of Medical Sciences, Poznań, Poland., Luite R; Heart Center, Kuopio University Hospital, Kuopio, Finland., Nikkinen M; Heart Center, Kuopio University Hospital, Kuopio, Finland., Qayyum AA; Cardiology Stem Cell Centre, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark., Haack-Sørensen M; Cardiology Stem Cell Centre, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark., Kelham M; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Jones DA; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Hamzaraj K; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Spannbauer A; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Fernández-Santos ME; Department of Cardiology, General University Gregorio Marañón Hospital, Madrid, Spain., Jędrzejek M; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland., Skoczyńska A; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland., Vartiainen N; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Knuuti J; Turku PET Centre, Turku University Hospital, Turku, Finland., Saraste A; Heart Center, Turku University Hospital, Turku, Finland., Ylä-Herttuala S; Heart Center, Kuopio University Hospital, Kuopio, Finland.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.
Source: Open heart [Open Heart] 2024 Oct 17; Vol. 11 (2). Date of Electronic Publication: 2024 Oct 17.
Publication Type: Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101631219 Publication Model: Electronic Cited Medium: Print ISSN: 2053-3624 (Print) Linking ISSN: 20533624 NLM ISO Abbreviation: Open Heart Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2053-3624
DOI:10.1136/openhrt-2024-002817