Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial.
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| Title: | Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial. |
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| Authors: | Leikas AJ; Heart Center, Kuopio University Hospital, Kuopio, Finland aleksi.leikas@uef.fi.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland., Hartikainen JEK; Heart Center, Kuopio University Hospital, Kuopio, Finland.; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Kastrup J; Cardiology Stem Cell Centre, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark., Mathur A; Centre for Cardiovascular Medicine and Devices, Queen Mary University of London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK.; NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Gyöngyösi M; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Fernández-Avilés F; Department of Cardiology, General University Gregorio Marañón Hospital, Madrid, Spain., Sanz-Ruiz R; Department of Cardiology, General University Gregorio Marañón Hospital, Madrid, Spain., Wojakowski W; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland., Gwizdała A; First Department of Cardiology, Poznań University of Medical Sciences, Poznań, Poland., Luite R; Heart Center, Kuopio University Hospital, Kuopio, Finland., Nikkinen M; Heart Center, Kuopio University Hospital, Kuopio, Finland., Qayyum AA; Cardiology Stem Cell Centre, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark., Haack-Sørensen M; Cardiology Stem Cell Centre, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark., Kelham M; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Jones DA; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Hamzaraj K; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Spannbauer A; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Fernández-Santos ME; Department of Cardiology, General University Gregorio Marañón Hospital, Madrid, Spain., Jędrzejek M; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland., Skoczyńska A; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland., Vartiainen N; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Knuuti J; Turku PET Centre, Turku University Hospital, Turku, Finland., Saraste A; Heart Center, Turku University Hospital, Turku, Finland., Ylä-Herttuala S; Heart Center, Kuopio University Hospital, Kuopio, Finland.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland. |
| Source: | Open heart [Open Heart] 2024 Oct 17; Vol. 11 (2). Date of Electronic Publication: 2024 Oct 17. |
| Publication Type: | Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101631219 Publication Model: Electronic Cited Medium: Print ISSN: 2053-3624 (Print) Linking ISSN: 20533624 NLM ISO Abbreviation: Open Heart Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39424303 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Leikas+AJ%22">Leikas AJ</searchLink>; Heart Center, Kuopio University Hospital, Kuopio, Finland aleksi.leikas@uef.fi.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Hartikainen+JEK%22">Hartikainen JEK</searchLink>; Heart Center, Kuopio University Hospital, Kuopio, Finland.; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Kastrup+J%22">Kastrup J</searchLink>; Cardiology Stem Cell Centre, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Mathur+A%22">Mathur A</searchLink>; Centre for Cardiovascular Medicine and Devices, Queen Mary University of London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK.; NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gyöngyösi+M%22">Gyöngyösi M</searchLink>; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Fernández-Avilés+F%22">Fernández-Avilés F</searchLink>; Department of Cardiology, General University Gregorio Marañón Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz-Ruiz+R%22">Sanz-Ruiz R</searchLink>; Department of Cardiology, General University Gregorio Marañón Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Wojakowski+W%22">Wojakowski W</searchLink>; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland.<br /><searchLink fieldCode="AU" term="%22Gwizdała+A%22">Gwizdała A</searchLink>; First Department of Cardiology, Poznań University of Medical Sciences, Poznań, Poland.<br /><searchLink fieldCode="AU" term="%22Luite+R%22">Luite R</searchLink>; Heart Center, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Nikkinen+M%22">Nikkinen M</searchLink>; Heart Center, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Qayyum+AA%22">Qayyum AA</searchLink>; Cardiology Stem Cell Centre, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Haack-Sørensen+M%22">Haack-Sørensen M</searchLink>; Cardiology Stem Cell Centre, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kelham+M%22">Kelham M</searchLink>; Barts Heart Centre, St Bartholomew's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Jones+DA%22">Jones DA</searchLink>; Barts Heart Centre, St Bartholomew's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Hamzaraj+K%22">Hamzaraj K</searchLink>; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Spannbauer+A%22">Spannbauer A</searchLink>; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Fernández-Santos+ME%22">Fernández-Santos ME</searchLink>; Department of Cardiology, General University Gregorio Marañón Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jędrzejek+M%22">Jędrzejek M</searchLink>; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland.<br /><searchLink fieldCode="AU" term="%22Skoczyńska+A%22">Skoczyńska A</searchLink>; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland.<br /><searchLink fieldCode="AU" term="%22Vartiainen+N%22">Vartiainen N</searchLink>; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Knuuti+J%22">Knuuti J</searchLink>; Turku PET Centre, Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Saraste+A%22">Saraste A</searchLink>; Heart Center, Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Ylä-Herttuala+S%22">Ylä-Herttuala S</searchLink>; Heart Center, Kuopio University Hospital, Kuopio, Finland.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101631219%22">Open heart</searchLink> [Open Heart] 2024 Oct 17; Vol. 11 (2). <i>Date of Electronic Publication: </i>2024 Oct 17. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group%22">BMJ Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101631219 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2053-3624 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220533624%22">20533624 </searchLink><i>NLM ISO Abbreviation: </i>Open Heart <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39424303 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1136/openhrt-2024-002817 Languages: – Code: eng Text: English Titles: – TitleFull: Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Leikas AJ – PersonEntity: Name: NameFull: Hartikainen JEK – PersonEntity: Name: NameFull: Kastrup J – PersonEntity: Name: NameFull: Mathur A – PersonEntity: Name: NameFull: Gyöngyösi M – PersonEntity: Name: NameFull: Fernández-Avilés F – PersonEntity: Name: NameFull: Sanz-Ruiz R – PersonEntity: Name: NameFull: Wojakowski W – PersonEntity: Name: NameFull: Gwizdała A – PersonEntity: Name: NameFull: Luite R – PersonEntity: Name: NameFull: Nikkinen M – PersonEntity: Name: NameFull: Qayyum AA – PersonEntity: Name: NameFull: Haack-Sørensen M – PersonEntity: Name: NameFull: Kelham M – PersonEntity: Name: NameFull: Jones DA – PersonEntity: Name: NameFull: Hamzaraj K – PersonEntity: Name: NameFull: Spannbauer A – PersonEntity: Name: NameFull: Fernández-Santos ME – PersonEntity: Name: NameFull: Jędrzejek M – PersonEntity: Name: NameFull: Skoczyńska A – PersonEntity: Name: NameFull: Vartiainen N – PersonEntity: Name: NameFull: Knuuti J – PersonEntity: Name: NameFull: Saraste A – PersonEntity: Name: NameFull: Ylä-Herttuala S IsPartOfRelationships: – BibEntity: Dates: – D: 17 M: 10 Text: 2024 Oct 17 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 2053-3624 Numbering: – Type: volume Value: 11 – Type: issue Value: 2 Titles: – TitleFull: Open heart Type: main |
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