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Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial.

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Title: Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial.
Authors: Silva M; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA., Wacker DA; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, 55455, USA., Driver BE; Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN, 55415, USA., Staugaitis A; Department of Emergency Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, 55414, USA., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Schmidt EL; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Kirkland JL; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, West Hollywood, CA, 90069, USA., Tchkonia T; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, West Hollywood, CA, 90069, USA., Evans T; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, West Hollywood, CA, 90069, USA., Serrano CH; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA., Ventz S; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA., Koopmeiners JS; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA., Puskarich MA; Department of Emergency Medicine, University of Minnesota School of Medicine and Hennepin Healthcare, Minneapolis, MN, 55455, USA. mike-em@umn.edu.
Corporate Authors: STOP-Sepsis Investigators
Source: Trials [Trials] 2024 Oct 21; Vol. 25 (1), pp. 698. Date of Electronic Publication: 2024 Oct 21.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Silva+M%22">Silva M</searchLink>; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Wacker+DA%22">Wacker DA</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Driver+BE%22">Driver BE</searchLink>; Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN, 55415, USA.<br /><searchLink fieldCode="AU" term="%22Staugaitis+A%22">Staugaitis A</searchLink>; Department of Emergency Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, 55414, USA.<br /><searchLink fieldCode="AU" term="%22Niedernhofer+LJ%22">Niedernhofer LJ</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+EL%22">Schmidt EL</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Kirkland+JL%22">Kirkland JL</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, West Hollywood, CA, 90069, USA.<br /><searchLink fieldCode="AU" term="%22Tchkonia+T%22">Tchkonia T</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, West Hollywood, CA, 90069, USA.<br /><searchLink fieldCode="AU" term="%22Evans+T%22">Evans T</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, West Hollywood, CA, 90069, USA.<br /><searchLink fieldCode="AU" term="%22Serrano+CH%22">Serrano CH</searchLink>; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Ventz+S%22">Ventz S</searchLink>; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Koopmeiners+JS%22">Koopmeiners JS</searchLink>; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Puskarich+MA%22">Puskarich MA</searchLink>; Department of Emergency Medicine, University of Minnesota School of Medicine and Hennepin Healthcare, Minneapolis, MN, 55455, USA. mike-em@umn.edu.
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