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FoxO1/Rictor axis induces a nongenetic adaptation to ibrutinib via Akt activation in chronic lymphocytic leukemia.

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Title: FoxO1/Rictor axis induces a nongenetic adaptation to ibrutinib via Akt activation in chronic lymphocytic leukemia.
Authors: Ondrisova L; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Seda V; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Hlavac K; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Pavelkova P; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Hoferkova E; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Chiodin G; Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Kostalova L; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Mladonicka Pavlasova G; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia., Filip D; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Vecera J; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Zeni PF; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia., Oppelt J; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia., Kahounova Z; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia., Vichova R; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia., Soucek K; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia., Panovska A; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Plevova K; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Pospisilova S; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Simkovic M; Fourth Department of Internal Medicine-Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia., Vrbacky F; Fourth Department of Internal Medicine-Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia., Lysak D; Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia., Fernandes SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Davids MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Maiques-Diaz A; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Charalampopoulou S; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Martin-Subero JI; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Brown JR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Doubek M; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Forconi F; Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom., Mayer J; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia., Mraz M; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.
Source: The Journal of clinical investigation [J Clin Invest] 2024 Oct 22; Vol. 134 (23). Date of Electronic Publication: 2024 Oct 22.
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: FoxO1/Rictor axis induces a nongenetic adaptation to ibrutinib via Akt activation in chronic lymphocytic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Ondrisova+L%22">Ondrisova L</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Seda+V%22">Seda V</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Hlavac+K%22">Hlavac K</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Pavelkova+P%22">Pavelkova P</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Hoferkova+E%22">Hoferkova E</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Chiodin+G%22">Chiodin G</searchLink>; Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kostalova+L%22">Kostalova L</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Mladonicka+Pavlasova+G%22">Mladonicka Pavlasova G</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Filip+D%22">Filip D</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Vecera+J%22">Vecera J</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Zeni+PF%22">Zeni PF</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Oppelt+J%22">Oppelt J</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Kahounova+Z%22">Kahounova Z</searchLink>; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Vichova+R%22">Vichova R</searchLink>; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Soucek+K%22">Soucek K</searchLink>; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Panovska+A%22">Panovska A</searchLink>; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Plevova+K%22">Plevova K</searchLink>; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Pospisilova+S%22">Pospisilova S</searchLink>; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Simkovic+M%22">Simkovic M</searchLink>; Fourth Department of Internal Medicine-Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.<br /><searchLink fieldCode="AU" term="%22Vrbacky+F%22">Vrbacky F</searchLink>; Fourth Department of Internal Medicine-Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.<br /><searchLink fieldCode="AU" term="%22Lysak+D%22">Lysak D</searchLink>; Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.<br /><searchLink fieldCode="AU" term="%22Fernandes+SM%22">Fernandes SM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Davids+MS%22">Davids MS</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Maiques-Diaz+A%22">Maiques-Diaz A</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Charalampopoulou+S%22">Charalampopoulou S</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martin-Subero+JI%22">Martin-Subero JI</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Brown+JR%22">Brown JR</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Doubek+M%22">Doubek M</searchLink>; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Forconi+F%22">Forconi F</searchLink>; Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mayer+J%22">Mayer J</searchLink>; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Mraz+M%22">Mraz M</searchLink>; Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2024 Oct 22; Vol. 134 (23). <i>Date of Electronic Publication: </i>2024 Oct 22.
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