Engineered AAV capsid transport mutants overcome transduction deficiencies in the aged CNS.

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Title: Engineered AAV capsid transport mutants overcome transduction deficiencies in the aged CNS.
Authors: Sandoval IM; Parkinson's Disease Research Unit, Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA., Kelley CM; Parkinson's Disease Research Unit, Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA., Bernal-Conde LD; Parkinson's Disease Research Unit, Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA., Steece-Collier K; Department of Translational Neuroscience, Michigan State University College of Human Medicine, Grand Rapids, MI 49506, USA., Marmion DJ; Parkinson's Disease Research Unit, Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA., Davidsson M; Parkinson's Disease Research Unit, Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA., Crosson SM; Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA., Boye SL; Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA., Boye SE; Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA., Manfredsson FP; Parkinson's Disease Research Unit, Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Source: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2024 Sep 12; Vol. 35 (4), pp. 102332. Date of Electronic Publication: 2024 Sep 12 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2162-2531
DOI:10.1016/j.omtn.2024.102332