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Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia.

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Title: Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia.
Authors: Wegmann R; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland., Bonilla X; Department of Computer Science, ETH Zurich, Zurich, Switzerland., Casanova R; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Chevrier S; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Coelho R; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Esposito C; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Ficek-Pascual J; Department of Computer Science, ETH Zurich, Zurich, Switzerland., Goetze S; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.; ETH PHRT Swiss Multi-Omics Center (SMOC), Lausanne, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Gut G; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Jacob F; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Jacobs A; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Kuipers J; Department of Biosystems Science and Engineering, ETH Zurich, Zurich, Switzerland., Lischetti U; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Mena J; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland., Milani ES; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Prummer M; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; NEXUS Personalized Health Technologies, ETH Zurich, Zurich, Switzerland., Del Castillo JS; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Singer F; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; NEXUS Personalized Health Technologies, ETH Zurich, Zurich, Switzerland., Sivapatham S; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Toussaint NC; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; NEXUS Personalized Health Technologies, ETH Zurich, Zurich, Switzerland.; Swiss Data Science Center, ETH Zürich, Zurich, Switzerland., Vilinovszki O; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland., Wildschut MHE; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland., Thavayogarajah T; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland., Malani D; Harvard Medical School and Dana-Farber Cancer Institute, Boston, USA., Aebersold R; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland., Bacac M; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Zurich, Switzerland., Beerenwinkel N; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Zurich, Switzerland., Beisel C; Department of Biosystems Science and Engineering, ETH Zurich, Zurich, Switzerland., Bodenmiller B; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Heinzelmann-Schwarz V; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Koelzer VH; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.; University of Zurich, Faculty of Medicine, Zurich, Switzerland., Levesque MP; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland., Moch H; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.; University of Zurich, Faculty of Medicine, Zurich, Switzerland., Pelkmans L; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Rätsch G; Department of Computer Science, ETH Zurich, Zurich, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; AI Center at ETH Zurich, Zurich, Switzerland., Tolnay M; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Wicki A; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.; University of Zurich, Faculty of Medicine, Zurich, Switzerland., Wollscheid B; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Manz MG; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland. markus.manz@usz.ch., Snijder B; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland. snijder@imsb.biol.ethz.ch.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland. snijder@imsb.biol.ethz.ch., Theocharides APA; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland. alexandre.theocharides@usz.ch.
Corporate Authors: TumorProfiler Consortium
Source: Nature communications [Nat Commun] 2024 Oct 30; Vol. 15 (1), pp. 9402. Date of Electronic Publication: 2024 Oct 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-024-53535-4