Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment.
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| Title: | Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment. |
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| Authors: | Sternberg C; Department of Pathology, Medical University of Vienna, Vienna, Austria. christina.sternberg@meduniwien.ac.at.; Biochemical Institute, University of Kiel, Kiel, Germany. christina.sternberg@meduniwien.ac.at.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria. christina.sternberg@meduniwien.ac.at., Raigel M; Department of Pathology, Medical University of Vienna, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria., Limberger T; Department of Pathology, Medical University of Vienna, Vienna, Austria.; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.; Center for Biomarker Research in Medicine GmbH (CBmed), Graz, Styria, Austria., Trachtová K; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.; Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Schlederer M; Department of Pathology, Medical University of Vienna, Vienna, Austria., Lindner D; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria., Kodajova P; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria., Yang J; Department of Pathology, Medical University of Vienna, Vienna, Austria., Ziegler R; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.; Department of Cell Biology, Charles University, Prague, Czech Republic and Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Vestec u Prahy, Czech Republic., Kalla J; Department of Pathology, Medical University of Vienna, Vienna, Austria., Stoiber S; Department of Pathology, Medical University of Vienna, Vienna, Austria.; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria., Dey S; Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria., Zwolanek D; Center for Cancer Research, Medical University of Vienna & Comprehensive Cancer Center, Vienna, Austria., Neubauer HA; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.; Institute of Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria., Oberhuber M; Center for Biomarker Research in Medicine GmbH (CBmed), Graz, Styria, Austria., Redmer T; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria., Hejret V; Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Tichy B; Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Tomberger M; Center for Biomarker Research in Medicine GmbH (CBmed), Graz, Styria, Austria., Harbusch NS; Center for Biomarker Research in Medicine GmbH (CBmed), Graz, Styria, Austria., Pencik J; Department of Pathology, Medical University of Vienna, Vienna, Austria., Tangermann S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria., Bystry V; Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Persson JL; Department of Molecular Biology, Umeå University, Umeå, Sweden.; Department of Biomedical Sciences, Malmö Universitet, Malmö, Sweden., Egger G; Department of Pathology, Medical University of Vienna, Vienna, Austria.; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Pospisilova S; Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Eferl R; Center for Cancer Research, Medical University of Vienna & Comprehensive Cancer Center, Vienna, Austria., Wolf P; Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria., Sternberg F; Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria.; Department of Biological Sciences and Pathobiology, Physiology and Biophysics, University of Veterinary Medicine Vienna, Vienna, Austria., Högler S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria., Lagger S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria., Rose-John S; Biochemical Institute, University of Kiel, Kiel, Germany. rosejohn@biochem.uni-kiel.de., Kenner L; Department of Pathology, Medical University of Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Center for Biomarker Research in Medicine GmbH (CBmed), Graz, Styria, Austria. lukas.kenner@meduniwien.ac.at.; Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at. |
| Source: | Molecular cancer [Mol Cancer] 2024 Oct 31; Vol. 23 (1), pp. 245. Date of Electronic Publication: 2024 Oct 31. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1476-4598 |
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| DOI: | 10.1186/s12943-024-02114-8 |
