ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.

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Bibliographic Details
Title: ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.
Authors: Gong GQ; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand., Masson GR; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB20QH, U.K., Lee WJ; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand., Dickson JMJ; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Kendall JD; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Rathinaswamy MK; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2., Buchanan CM; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand., Middleditch M; School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Owen BM; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Spicer JA; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Rewcastle GW; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Denny WA; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2., Shepherd PR; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Williams RL; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB20QH, U.K., Flanagan JU; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.
Source: The Biochemical journal [Biochem J] 2024 Dec 04; Vol. 481 (23), pp. 1787-1802.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1470-8728
DOI:10.1042/BCJ20240479