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ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.

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Title: ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.
Authors: Gong GQ; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand., Masson GR; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB20QH, U.K., Lee WJ; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand., Dickson JMJ; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Kendall JD; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Rathinaswamy MK; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2., Buchanan CM; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand., Middleditch M; School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Owen BM; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Spicer JA; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Rewcastle GW; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Denny WA; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2., Shepherd PR; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Williams RL; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB20QH, U.K., Flanagan JU; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.
Source: The Biochemical journal [Biochem J] 2024 Dec 04; Vol. 481 (23), pp. 1787-1802.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
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  Data: ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.
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  Data: <searchLink fieldCode="AU" term="%22Gong+GQ%22">Gong GQ</searchLink>; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Masson+GR%22">Masson GR</searchLink>; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB20QH, U.K.<br /><searchLink fieldCode="AU" term="%22Lee+WJ%22">Lee WJ</searchLink>; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Dickson+JMJ%22">Dickson JMJ</searchLink>; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; School of Biological Sciences, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Kendall+JD%22">Kendall JD</searchLink>; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Rathinaswamy+MK%22">Rathinaswamy MK</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2.<br /><searchLink fieldCode="AU" term="%22Buchanan+CM%22">Buchanan CM</searchLink>; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Middleditch+M%22">Middleditch M</searchLink>; School of Biological Sciences, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Owen+BM%22">Owen BM</searchLink>; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Spicer+JA%22">Spicer JA</searchLink>; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Rewcastle+GW%22">Rewcastle GW</searchLink>; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Denny+WA%22">Denny WA</searchLink>; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Burke+JE%22">Burke JE</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2.<br /><searchLink fieldCode="AU" term="%22Shepherd+PR%22">Shepherd PR</searchLink>; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Williams+RL%22">Williams RL</searchLink>; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB20QH, U.K.<br /><searchLink fieldCode="AU" term="%22Flanagan+JU%22">Flanagan JU</searchLink>; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.
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