Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis.

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Title: Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis.
Authors: Klimtchuk ES; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States. Electronic address: klimtchu@bu.edu., Prokaeva T; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States; Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, United States. Electronic address: prokaeva@bu.edu., Spencer BH; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States. Electronic address: bspencer@bu.edu., Wong S; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States. Electronic address: sw671@bu.edu., Ghosh S; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: sh.ghosh@northeastern.edu., Urdaneta A; Department of Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medicine, Boston University, 700 Albany Street, Boston, MA 02118, United States. Electronic address: angelau@bu.edu., Morgan G; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States. Electronic address: gjmorgan@bu.edu., Wales TE; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: T.Wales@northeastern.edu., Gursky O; Department of Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medicine, Boston University, 700 Albany Street, Boston, MA 02118, United States. Electronic address: Gursky@bu.edu.
Source: Journal of molecular biology [J Mol Biol] 2024 Dec 01; Vol. 436 (23), pp. 168837. Date of Electronic Publication: 2024 Oct 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1089-8638
DOI:10.1016/j.jmb.2024.168837