Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa.
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| Title: | Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa. |
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| Authors: | Cummings MJ; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.; Center for Infection and Immunity., Lutwama JJ; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Owor N; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Tomoiaga AS; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.; Department of Accounting, Business Analytics, Computer Information Systems, and Law, Manhattan College, New York, New York., Ross JE; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine., Muwanga M; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Nsereko C; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Nayiga I; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Kyebambe S; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Shinyale J; Entebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda., Ochar T; Tororo General Hospital, Ministry of Health, Tororo, Uganda., Kiwubeyi M; Tororo General Hospital, Ministry of Health, Tororo, Uganda., Nankwanga R; Tororo General Hospital, Ministry of Health, Tororo, Uganda., Nie K; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Xie H; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Miake-Lye S; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Villagomez B; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Qi J; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Reynolds SJ; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Rakai Health Sciences Program, Kalisizo, Uganda; and., Nakibuuka MC; Rakai Health Sciences Program, Kalisizo, Uganda; and., Lu X; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine., Kayiwa J; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Haumba M; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Nakaseegu J; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and., Che X; Center for Infection and Immunity.; Department of Biostatistics, and., Wayengera M; Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda., Ghosh S; Department of Microbiology and Immunology, and., Kim-Schulze S; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York., Lipkin WI; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons.; Center for Infection and Immunity.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York., Bakamutumaho B; Department of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.; Immunizable Diseases Unit, Uganda Virus Research Institute, Entebbe, Uganda., O'Donnell MR; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.; Center for Infection and Immunity.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. |
| Source: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2025 Mar; Vol. 211 (3), pp. 357-369. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1535-4970 |
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| DOI: | 10.1164/rccm.202407-1394OC |
