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Bioactive fraction of Musa balbisiana seed mitigates D-galactose-induced brain aging via SIRT1/PGC-1α/FoxO3a activation and intestinal barrier dysfunction by modulating gut microbiota and core metabolites.

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Title: Bioactive fraction of Musa balbisiana seed mitigates D-galactose-induced brain aging via SIRT1/PGC-1α/FoxO3a activation and intestinal barrier dysfunction by modulating gut microbiota and core metabolites.
Authors: Gurumayum N; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India; Department of Zoology, Gauhati University, Guwahati, 781014, India., Devi MB; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India; Department of Biotechnology, Gauhati University, Guwahati, 781014, India., Khound P; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India; Department of Zoology, Gauhati University, Guwahati, 781014, India., Bhattacharya A; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India., Sarma H; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India., Khan MR; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India. Electronic address: mojibur.khan@iasst.gov.in., Devi R; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India; Department of Zoology, Gauhati University, Guwahati, 781014, India. Electronic address: rajiasst@gmail.com.
Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Jan; Vol. 226, pp. 43-55. Date of Electronic Publication: 2024 Nov 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-4596
DOI:10.1016/j.freeradbiomed.2024.11.016