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Plant-produced SARS-CoV-2 antibody engineered towards enhanced potency and in vivo efficacy.

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Title: Plant-produced SARS-CoV-2 antibody engineered towards enhanced potency and in vivo efficacy.
Authors: de Taeye SW; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands., Faye L; ANGANY Innovation, 1 voie de l'innovation, Pharmaparc II, Val de Reuil, France., Morel B; ANGANY Innovation, 1 voie de l'innovation, Pharmaparc II, Val de Reuil, France., Schriek AI; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands., Umotoy JC; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands., Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA., Kuzmina NA; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA., Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA., Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA., Grünwald-Gruber C; BOKU Core Facility Mass Spectrometry, Universität für Bodenkultur Wien, Vienna, Austria., Poniman M; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands., Burger JA; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands., Caniels TG; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands., Fitchette AC; ANGANY Innovation, 1 voie de l'innovation, Pharmaparc II, Val de Reuil, France., Desgagnés R; ANGANY Inc, Québec, Quebec, Canada., Stordeur V; ANGANY Innovation, 1 voie de l'innovation, Pharmaparc II, Val de Reuil, France., Mirande L; ANGANY Innovation, 1 voie de l'innovation, Pharmaparc II, Val de Reuil, France., Beauverger G; ANGANY Innovation, 1 voie de l'innovation, Pharmaparc II, Val de Reuil, France., de Bree G; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA., Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Galveston National Laboratory, Galveston, Texas, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA., Sanders RW; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands.; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA., Vezina LP; ANGANY Inc, Québec, Quebec, Canada., Beaumont T; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands., van Gils MJ; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, The Netherlands., Gomord V; ANGANY Innovation, 1 voie de l'innovation, Pharmaparc II, Val de Reuil, France.; ANGANY Inc, Québec, Quebec, Canada.
Source: Plant biotechnology journal [Plant Biotechnol J] 2025 Jan; Vol. 23 (1), pp. 4-16. Date of Electronic Publication: 2024 Nov 19.
Publication Type: Journal Article
Journal Info: Publisher: Wiley on behalf of the Society for Experimental Biology, Association of Applied Biologists Country of Publication: England NLM ID: 101201889 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-7652 (Electronic) Linking ISSN: 14677644 NLM ISO Abbreviation: Plant Biotechnol J Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1467-7652
DOI:10.1111/pbi.14458