Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids.

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Title: Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids.
Authors: Kluiver TA; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., Lu Y; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands.; Department of Hepatobiliary Surgery, Xiamen Hospital of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Xiamen, China., Schubert SA; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., Kraaier LJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., Ringnalda F; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., Lijnzaad P; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., DeMartino J; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Megchelenbrink WL; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands.; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. De Crecchio 7, Naples, Italy., Amo-Addae V; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., Eising S; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., de Faria FW; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, Münster, Germany., Münter D; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, Münster, Germany., van de Wetering M; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., Kerl K; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, Münster, Germany., Duiker E; Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands., van den Heuvel MC; Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands., de Meijer VE; Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., de Kleine RH; Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., Margaritis T; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., Stunnenberg HG; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., de Krijger RR; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands.; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, the Netherlands., Zsiros J; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands., Clevers H; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, the Netherlands.; Pharma, Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Basel, Switzerland., Peng WC; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, the Netherlands. w.c.peng@prinsesmaximacentrum.nl.
Source: Nature communications [Nat Commun] 2024 Nov 20; Vol. 15 (1), pp. 8576. Date of Electronic Publication: 2024 Nov 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-024-52757-w