A framework for conducting GWAS using repeated measures data with an application to childhood BMI.

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Title: A framework for conducting GWAS using repeated measures data with an application to childhood BMI.
Authors: Burrows K; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Heiskala A; Research Unit of Population Health, University of Oulu, Oulu, Finland., Bradfield JP; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Quantinuum Research LLC, Wayne, PA, USA., Balkhiyarova Z; Department of Clinical and Experimental Medicine, School of Biosciences, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; National Heart & Lung Institute, Imperial College London, London, UK., Ning L; Univ Lille, INSERM/CNRS UMR1283/8199, EGID, Institut Pasteur de Lille, Lille University Hospital, Lille, France., Boissel M; Univ Lille, INSERM/CNRS UMR1283/8199, EGID, Institut Pasteur de Lille, Lille University Hospital, Lille, France., Chan YM; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Froguel P; Univ Lille, INSERM/CNRS UMR1283/8199, EGID, Institut Pasteur de Lille, Lille University Hospital, Lille, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom., Bonnefond A; Univ Lille, INSERM/CNRS UMR1283/8199, EGID, Institut Pasteur de Lille, Lille University Hospital, Lille, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Alves AC; School of Biosciences and Medicine, University of Surrey, Guildford, UK., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kaakinen M; Department of Clinical and Experimental Medicine, School of Biosciences, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Järvelin MR; Research Unit of Population Health, University of Oulu, Oulu, Finland.; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, United Kingdom., Grant SFA; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Divisions of Human Genetics and Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Tilling K; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK., Prokopenko I; Department of Clinical and Experimental Medicine, School of Biosciences, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK., Sebert S; Research Unit of Population Health, University of Oulu, Oulu, Finland. Sylvain.Sebert@oulu.fi., Canouil M; Univ Lille, INSERM/CNRS UMR1283/8199, EGID, Institut Pasteur de Lille, Lille University Hospital, Lille, France., Warrington NM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. n.warrington@uq.edu.au.; Frazer Institute, University of Queensland, Brisbane, Australia. n.warrington@uq.edu.au.
Source: Nature communications [Nat Commun] 2024 Nov 20; Vol. 15 (1), pp. 10067. Date of Electronic Publication: 2024 Nov 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-024-53687-3