Rapid in silico directed evolution by a protein language model with EVOLVEpro.
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| Title: | Rapid in silico directed evolution by a protein language model with EVOLVEpro. |
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| Authors: | Jiang K; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.; Department of Bioengineering Massachusetts Institute of Technology, Cambridge, MA, USA., Yan Z; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Di Bernardo M; Whitehead Institute Massachusetts Institute of Technology, Cambridge, MA, USA., Sgrizzi SR; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Villiger L; Department of Dermatology and Allergology Kantonspital St. Gallen, St. Gallen, Switzerland., Kayabolen A; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Kim BJ; Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology, Cambridge, MA, USA., Carscadden JK; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Hiraizumi M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan., Nishimasu H; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.; Structural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, Japan.; Inamori Research Institute for Science, 620 Suiginya-cho, Shimogyo-ku, Kyoto, Japan., Gootenberg JS; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Abudayyeh OO; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA. |
| Source: | Science (New York, N.Y.) [Science] 2025 Jan 24; Vol. 387 (6732), pp. eadr6006. Date of Electronic Publication: 2025 Jan 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adr6006 |
