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Rapid in silico directed evolution by a protein language model with EVOLVEpro.

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Title: Rapid in silico directed evolution by a protein language model with EVOLVEpro.
Authors: Jiang K; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.; Department of Bioengineering Massachusetts Institute of Technology, Cambridge, MA, USA., Yan Z; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Di Bernardo M; Whitehead Institute Massachusetts Institute of Technology, Cambridge, MA, USA., Sgrizzi SR; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Villiger L; Department of Dermatology and Allergology Kantonspital St. Gallen, St. Gallen, Switzerland., Kayabolen A; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Kim BJ; Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology, Cambridge, MA, USA., Carscadden JK; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Hiraizumi M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan., Nishimasu H; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.; Structural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, Japan.; Inamori Research Institute for Science, 620 Suiginya-cho, Shimogyo-ku, Kyoto, Japan., Gootenberg JS; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA., Abudayyeh OO; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.
Source: Science (New York, N.Y.) [Science] 2025 Jan 24; Vol. 387 (6732), pp. eadr6006. Date of Electronic Publication: 2025 Jan 24.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Jiang+K%22">Jiang K</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.; Department of Bioengineering Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yan+Z%22">Yan Z</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Di+Bernardo+M%22">Di Bernardo M</searchLink>; Whitehead Institute Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sgrizzi+SR%22">Sgrizzi SR</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Villiger+L%22">Villiger L</searchLink>; Department of Dermatology and Allergology Kantonspital St. Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kayabolen+A%22">Kayabolen A</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+BJ%22">Kim BJ</searchLink>; Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Carscadden+JK%22">Carscadden JK</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hiraizumi+M%22">Hiraizumi M</searchLink>; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimasu+H%22">Nishimasu H</searchLink>; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.; Structural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, Japan.; Inamori Research Institute for Science, 620 Suiginya-cho, Shimogyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Gootenberg+JS%22">Gootenberg JS</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Abudayyeh+OO%22">Abudayyeh OO</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.
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        Value: 10.1126/science.adr6006
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