Affinity-tuned mesothelin CAR T cells demonstrate enhanced targeting specificity and reduced off-tumor toxicity.

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Bibliographic Details
Title: Affinity-tuned mesothelin CAR T cells demonstrate enhanced targeting specificity and reduced off-tumor toxicity.
Authors: Yang Y; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Vedvyas Y; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Alcaina Y; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Trumper SJ; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA., Babu DS; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA., Min IM; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Tremblay JM; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA., Shoemaker CB; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA., Jin MM; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA.
Source: JCI insight [JCI Insight] 2024 Nov 22; Vol. 9 (22). Date of Electronic Publication: 2024 Nov 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-3708
DOI:10.1172/jci.insight.186268