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Affinity-tuned mesothelin CAR T cells demonstrate enhanced targeting specificity and reduced off-tumor toxicity.

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Title: Affinity-tuned mesothelin CAR T cells demonstrate enhanced targeting specificity and reduced off-tumor toxicity.
Authors: Yang Y; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Vedvyas Y; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Alcaina Y; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Trumper SJ; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA., Babu DS; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA., Min IM; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Tremblay JM; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA., Shoemaker CB; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA., Jin MM; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA.
Source: JCI insight [JCI Insight] 2024 Nov 22; Vol. 9 (22). Date of Electronic Publication: 2024 Nov 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Affinity-tuned mesothelin CAR T cells demonstrate enhanced targeting specificity and reduced off-tumor toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Vedvyas+Y%22">Vedvyas Y</searchLink>; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Alcaina+Y%22">Alcaina Y</searchLink>; Department of Radiology, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Trumper+SJ%22">Trumper SJ</searchLink>; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Babu+DS%22">Babu DS</searchLink>; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Min+IM%22">Min IM</searchLink>; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Tremblay+JM%22">Tremblay JM</searchLink>; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Shoemaker+CB%22">Shoemaker CB</searchLink>; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jin+MM%22">Jin MM</searchLink>; Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.; Department of Radiology, Weill Cornell Medicine, New York, New York, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2024 Nov 22; Vol. 9 (22). <i>Date of Electronic Publication: </i>2024 Nov 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101676073 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2379-3708 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223793708%22">23793708 </searchLink><i>NLM ISO Abbreviation: </i>JCI Insight <i>Subsets: </i>MEDLINE
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        Value: 10.1172/jci.insight.186268
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      – Code: eng
        Text: English
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      – TitleFull: Affinity-tuned mesothelin CAR T cells demonstrate enhanced targeting specificity and reduced off-tumor toxicity.
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              Text: 2024 Nov 22
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