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Inceptor binds to and directs insulin towards lysosomal degradation in β cells.

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Title: Inceptor binds to and directs insulin towards lysosomal degradation in β cells.
Authors: Siehler J; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany., Bilekova S; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany., Chapouton P; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Dema A; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Albanese P; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.; Proteomics Centre, Utrecht, The Netherlands.; Université Grenoble Alpes, IRIG, CEA, CNRS, INRAE, UMR 5168, 38000, Grenoble, France.; Université Grenoble Alpes, INSERM, IRIG, CEA, UA13 BGE, CNRS, CEA, FR2048 ProFI, 38000, Grenoble, France., Tamara S; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.; Proteomics Centre, Utrecht, The Netherlands., Jain C; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Sterr M; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Enos SJ; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Physiology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Dresden University of Technology, Dresden, Germany., Chen C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Physiology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Dresden University of Technology, Dresden, Germany., Malhotra C; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; TUM School of Life Sciences, Technische Universität München, Freising, Germany., Villalba A; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Schomann L; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany., Bhattacharya S; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany., Feng J; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany., Akgün Canan M; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany., Ribaudo F; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Ansarullah; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Burtscher I; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Ahlbrecht C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Medicinal Chemistry, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Organic Chemistry (BMWZ) and Laboratory for Nano- and Quantum Engineering (LNQE), Center of Biomolecular Research, Leibniz, University Hannover, Hannover, Germany., Plettenburg O; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Medicinal Chemistry, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Organic Chemistry (BMWZ) and Laboratory for Nano- and Quantum Engineering (LNQE), Center of Biomolecular Research, Leibniz, University Hannover, Hannover, Germany.; Institute of Lung Health (ILH), Giessen, Germany., Kurth T; Center for Molecular and Cellular Bioengineering (CMCB), Technology Platform, Core Facility Electron Microscopy and Histology, Dresden University of Technology, Dresden, Germany., Scharfmann R; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Speier S; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Physiology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Dresden University of Technology, Dresden, Germany., Scheltema RA; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.; Proteomics Centre, Utrecht, The Netherlands.; Center for Proteome, Research and Department of Biochemistry, University of Liverpool, Liverpool, UK., Lickert H; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany. heiko.lickert@helmholtz-munich.de.; German Center for Diabetes Research (DZD), Neuherberg, Germany. heiko.lickert@helmholtz-munich.de.; School of Medicine and Health, Technische Universität München, Munich, Germany. heiko.lickert@helmholtz-munich.de.
Source: Nature metabolism [Nat Metab] 2024 Dec; Vol. 6 (12), pp. 2374-2390. Date of Electronic Publication: 2024 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inceptor binds to and directs insulin towards lysosomal degradation in β cells.
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  Data: <searchLink fieldCode="AU" term="%22Siehler+J%22">Siehler J</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bilekova+S%22">Bilekova S</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Chapouton+P%22">Chapouton P</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dema+A%22">Dema A</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Albanese+P%22">Albanese P</searchLink>; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.; Proteomics Centre, Utrecht, The Netherlands.; Université Grenoble Alpes, IRIG, CEA, CNRS, INRAE, UMR 5168, 38000, Grenoble, France.; Université Grenoble Alpes, INSERM, IRIG, CEA, UA13 BGE, CNRS, CEA, FR2048 ProFI, 38000, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Tamara+S%22">Tamara S</searchLink>; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.; Proteomics Centre, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jain+C%22">Jain C</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sterr+M%22">Sterr M</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Enos+SJ%22">Enos SJ</searchLink>; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Physiology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Physiology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Malhotra+C%22">Malhotra C</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; TUM School of Life Sciences, Technische Universität München, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Villalba+A%22">Villalba A</searchLink>; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.<br /><searchLink fieldCode="AU" term="%22Schomann+L%22">Schomann L</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bhattacharya+S%22">Bhattacharya S</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Feng+J%22">Feng J</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Akgün+Canan+M%22">Akgün Canan M</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; School of Medicine and Health, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ribaudo+F%22">Ribaudo F</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ansarullah%22">Ansarullah</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Burtscher+I%22">Burtscher I</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ahlbrecht+C%22">Ahlbrecht C</searchLink>; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Medicinal Chemistry, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Organic Chemistry (BMWZ) and Laboratory for Nano- and Quantum Engineering (LNQE), Center of Biomolecular Research, Leibniz, University Hannover, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Plettenburg+O%22">Plettenburg O</searchLink>; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Medicinal Chemistry, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Organic Chemistry (BMWZ) and Laboratory for Nano- and Quantum Engineering (LNQE), Center of Biomolecular Research, Leibniz, University Hannover, Hannover, Germany.; Institute of Lung Health (ILH), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Kurth+T%22">Kurth T</searchLink>; Center for Molecular and Cellular Bioengineering (CMCB), Technology Platform, Core Facility Electron Microscopy and Histology, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Scharfmann+R%22">Scharfmann R</searchLink>; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.<br /><searchLink fieldCode="AU" term="%22Speier+S%22">Speier S</searchLink>; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Physiology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Scheltema+RA%22">Scheltema RA</searchLink>; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.; Proteomics Centre, Utrecht, The Netherlands.; Center for Proteome, Research and Department of Biochemistry, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Lickert+H%22">Lickert H</searchLink>; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany. heiko.lickert@helmholtz-munich.de.; German Center for Diabetes Research (DZD), Neuherberg, Germany. heiko.lickert@helmholtz-munich.de.; School of Medicine and Health, Technische Universität München, Munich, Germany. heiko.lickert@helmholtz-munich.de.
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