The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations.
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| Title: | The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations. |
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| Authors: | Pallaseni A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Peets EM; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Girling G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Crepaldi L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Kuzmin I; Department of Computer Science, University of Tartu, Tartu, Estonia., Moor M; Department of Computer Science, University of Tartu, Tartu, Estonia., Muñoz-Subirana N; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Schimmel J; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Serçin Ö; BioMed X Institute (GmbH), Heidelberg, Germany., Mardin BR; BioMed X Institute (GmbH), Heidelberg, Germany.; Research Unit Oncology, Merck Healthcare KGaA, Darmstadt, Germany., Tijsterman M; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Institute of Biology Leiden, Leiden University, Leiden, The Netherlands., Peterson H; Department of Computer Science, University of Tartu, Tartu, Estonia., Kosicki M; Department of Medicine, University of Cambridge, Cambridge, UK. mkosicki@lbl.gov.; Lawrence Berkeley National Laboratory, Berkeley, CA, USA. mkosicki@lbl.gov., Parts L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. leopold.parts@sanger.ac.uk.; Department of Computer Science, University of Tartu, Tartu, Estonia. leopold.parts@sanger.ac.uk. |
| Source: | Nature communications [Nat Commun] 2024 Nov 27; Vol. 15 (1), pp. 10271. Date of Electronic Publication: 2024 Nov 27. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-54566-7 |
