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The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations.

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Title: The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations.
Authors: Pallaseni A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Peets EM; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Girling G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Crepaldi L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Kuzmin I; Department of Computer Science, University of Tartu, Tartu, Estonia., Moor M; Department of Computer Science, University of Tartu, Tartu, Estonia., Muñoz-Subirana N; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Schimmel J; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Serçin Ö; BioMed X Institute (GmbH), Heidelberg, Germany., Mardin BR; BioMed X Institute (GmbH), Heidelberg, Germany.; Research Unit Oncology, Merck Healthcare KGaA, Darmstadt, Germany., Tijsterman M; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Institute of Biology Leiden, Leiden University, Leiden, The Netherlands., Peterson H; Department of Computer Science, University of Tartu, Tartu, Estonia., Kosicki M; Department of Medicine, University of Cambridge, Cambridge, UK. mkosicki@lbl.gov.; Lawrence Berkeley National Laboratory, Berkeley, CA, USA. mkosicki@lbl.gov., Parts L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. leopold.parts@sanger.ac.uk.; Department of Computer Science, University of Tartu, Tartu, Estonia. leopold.parts@sanger.ac.uk.
Source: Nature communications [Nat Commun] 2024 Nov 27; Vol. 15 (1), pp. 10271. Date of Electronic Publication: 2024 Nov 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations.
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  Data: <searchLink fieldCode="AU" term="%22Pallaseni+A%22">Pallaseni A</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Peets+EM%22">Peets EM</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Girling+G%22">Girling G</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Crepaldi+L%22">Crepaldi L</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Kuzmin+I%22">Kuzmin I</searchLink>; Department of Computer Science, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Moor+M%22">Moor M</searchLink>; Department of Computer Science, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Muñoz-Subirana+N%22">Muñoz-Subirana N</searchLink>; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schimmel+J%22">Schimmel J</searchLink>; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Serçin+Ö%22">Serçin Ö</searchLink>; BioMed X Institute (GmbH), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mardin+BR%22">Mardin BR</searchLink>; BioMed X Institute (GmbH), Heidelberg, Germany.; Research Unit Oncology, Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Tijsterman+M%22">Tijsterman M</searchLink>; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Institute of Biology Leiden, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Peterson+H%22">Peterson H</searchLink>; Department of Computer Science, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Kosicki+M%22">Kosicki M</searchLink>; Department of Medicine, University of Cambridge, Cambridge, UK. mkosicki@lbl.gov.; Lawrence Berkeley National Laboratory, Berkeley, CA, USA. mkosicki@lbl.gov.<br /><searchLink fieldCode="AU" term="%22Parts+L%22">Parts L</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. leopold.parts@sanger.ac.uk.; Department of Computer Science, University of Tartu, Tartu, Estonia. leopold.parts@sanger.ac.uk.
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