Vasculogenic skin reprogramming requires TET-mediated gene demethylation in fibroblasts for rescuing impaired perfusion in diabetes.
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| Title: | Vasculogenic skin reprogramming requires TET-mediated gene demethylation in fibroblasts for rescuing impaired perfusion in diabetes. |
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| Authors: | Mohanty SK; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Singh K; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Kumar M; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Verma SS; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Srivastava R; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Gnyawali SC; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Palakurti R; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Sahi AK; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., El Masry MS; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Banerjee P; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Kacar S; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Rustagi Y; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Verma P; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Ghatak S; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Hernandez E; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Rubin JP; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA., Khanna S; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Roy S; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Yoder MC; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA., Sen CK; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. c.k.sen@pitt.edu.; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. c.k.sen@pitt.edu.; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA. c.k.sen@pitt.edu.; Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA. c.k.sen@pitt.edu. |
| Source: | Nature communications [Nat Commun] 2024 Nov 27; Vol. 15 (1), pp. 10277. Date of Electronic Publication: 2024 Nov 27. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-54385-w |
