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Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps.

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Title: Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps.
Authors: Guo CL; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Wang CS; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Wang ZC; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Liu FF; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Liu L; Wuhan Biobank, Wuhan, China., Yang Y; Frazer Institute, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.; Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Li X; Wuhan Biobank, Wuhan, China., Guo B; Department of Otolaryngology-Head and Neck Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Lu RY; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Liao B; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Liu JX; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Wang H; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Song J; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Yao Y; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China., Zhu LP; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Yu D; Frazer Institute, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia. di.yu@uq.edu.au.; Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia. di.yu@uq.edu.au., Liu Z; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China. zhengliuent@hotmail.com.; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China. zhengliuent@hotmail.com.; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, P.R. China. zhengliuent@hotmail.com.
Source: Nature communications [Nat Commun] 2024 Nov 29; Vol. 15 (1), pp. 10413. Date of Electronic Publication: 2024 Nov 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-024-54685-1